STRINGSTRING
CRKL CRKL ITGA2B ITGA2B PRKCA PRKCA FLT1 FLT1 MAPK12 MAPK12 RASSF5 RASSF5 CRK CRK FGF22 FGF22 PFN4 PFN4 RALB RALB ADCY3 ADCY3 FGF16 FGF16 GNAO1 GNAO1 BRAF BRAF SIPA1L2 SIPA1L2 FLT4 FLT4 SKAP1 SKAP1 MAP2K6 MAP2K6 GNAQ GNAQ RALA RALA FGF23 FGF23 FGF6 FGF6 CSF1 CSF1 TIAM1 TIAM1 GRIN2B GRIN2B RAP1A RAP1A MRAS MRAS PIK3CB PIK3CB LPAR5 LPAR5 FGF21 FGF21 PARD6A PARD6A VEGFB VEGFB PLCB3 PLCB3 KRAS KRAS CDH1 CDH1 KITLG KITLG PIK3CA PIK3CA SIPA1 SIPA1 CTNNB1 CTNNB1 PIK3R2 PIK3R2 FGF7 FGF7 PRKCG PRKCG RAPGEF2 RAPGEF2 RHOA RHOA GNAI2 GNAI2 PARD6B PARD6B EPHA2 EPHA2 PDGFA PDGFA HRAS HRAS KIT KIT FGF5 FGF5 MAPK13 MAPK13 VEGFD VEGFD GNAI1 GNAI1 ID1 ID1 ARAP3 ARAP3 FGF1 FGF1 LPAR3 LPAR3 CSF1R CSF1R PDGFRB PDGFRB FGF19 FGF19 EFNA5 EFNA5 DOCK4 DOCK4 ADCY2 ADCY2 TLN2 TLN2 FGFR1 FGFR1 RAPGEF6 RAPGEF6 F2R F2R FGFR4 FGFR4 PLCE1 PLCE1 RALGDS RALGDS CALML4 CALML4 FGF9 FGF9 INS-IGF2 INS-IGF2 PLCB1 PLCB1 PLCB4 PLCB4 ADORA2B ADORA2B FGF8 FGF8 ANGPT2 ANGPT2 PDGFB PDGFB ADORA2A ADORA2A PRKD1 PRKD1 PRKD3 PRKD3 TEK TEK EGF EGF RAPGEF5 RAPGEF5 VEGFC VEGFC APBB1IP APBB1IP FGFR2 FGFR2 LPAR1 LPAR1 LOC101176289 LOC101176289 P2RY1 P2RY1 LPAR4 LPAR4 ACTG1 ACTG1 PRKCI PRKCI AKT3 AKT3 HGF HGF RAF1 RAF1 MAPK14 MAPK14 MET MET EFNA3 EFNA3 PDGFD PDGFD KRIT1 KRIT1 FGF20 FGF20 FYB1 FYB1 EFNA1 EFNA1 MAPK1 MAPK1 CALML3 CALML3 AKT1 AKT1 PARD3 PARD3 FGF10 FGF10 NGF NGF DRD2 DRD2 CALM1 CALM1 MAGI3 MAGI3 RASGRP3 RASGRP3 ITGB1 ITGB1 PIK3R1 PIK3R1 ITGB3 ITGB3 PGF PGF TLN1 TLN1 PFN3 PFN3 EGFR EGFR MAP2K1 MAP2K1 RASGRP2 RASGRP2 FGF2 FGF2 EFNA2 EFNA2 ADCY8 ADCY8 FGF17 FGF17 PDGFC PDGFC NRAS NRAS CDC42 CDC42 ANGPT1 ANGPT1 CTNND1 CTNND1 GNAI3 GNAI3 GRIN2A GRIN2A EFNA4 EFNA4 RAC2 RAC2 PRKCB PRKCB THBS1 THBS1 KDR KDR IGF1 IGF1 LPAR2 LPAR2 PIK3R3 PIK3R3 PFN1-2 PFN1-2 ADCY1 ADCY1 SIPA1L1 SIPA1L1 LCP2 LCP2 ADCY5 ADCY5 ENAH ENAH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1040 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
RASSF5Ras association domain family member 5. (418 aa)
CRKUncharacterized protein. (252 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PFN4Profilin; Belongs to the profilin family. (128 aa)
RALBRAS like proto-oncogene B. (212 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GNAO1G protein subunit alpha o1. (353 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
SIPA1L2Signal induced proliferation associated 1 like 2. (1722 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
SKAP1Src kinase associated phosphoprotein 1. (359 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GNAQG protein subunit alpha q. (358 aa)
RALARAS like proto-oncogene A. (206 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1561 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1335 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
SIPA1Signal-induced proliferation-associated 1. (1022 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R2Uncharacterized protein. (727 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1642 aa)
RHOARas homolog family member A. (193 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
EPHA2EPH receptor A2. (976 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GNAI1G protein subunit alpha i1. (353 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (155 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1531 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (342 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (2019 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
TLN2Uncharacterized protein. (2289 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
RAPGEF6Uncharacterized protein. (1609 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
RALGDSUncharacterized protein. (916 aa)
CALML4Calmodulin like 4. (196 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
ANGPT2Angiopoietin 2. (496 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (667 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
LOC101176289Uncharacterized protein. (244 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ACTG1Actin gamma 1. (378 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
KRIT1Uncharacterized protein. (736 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FYB1FYN binding protein 1. (839 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PARD3Par-3 family cell polarity regulator. (1273 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1481 aa)
RASGRP3RAS guanyl releasing protein 3. (690 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
TLN1Talin 1. (2542 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RASGRP2RAS guanyl releasing protein 2. (610 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
EFNA2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (195 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CDC42Cell division cycle 42. (191 aa)
ANGPT1Angiopoietin 1. (498 aa)
CTNND1Catenin delta 1. (968 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
EFNA4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (201 aa)
RAC2Rac family small GTPase 2. (192 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
THBS1Thrombospondin 1. (1173 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
IGF1IlGF domain-containing protein. (196 aa)
LPAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (297 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PFN1-2Profilin; Belongs to the profilin family. (128 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1780 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
ENAHWH1 domain-containing protein. (805 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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