STRINGSTRING
BDKRB2 BDKRB2 ADCY3 ADCY3 GNAQ GNAQ ITPR1 ITPR1 LOC100600502 LOC100600502 NOS3 NOS3 SRF SRF CREB3 CREB3 PDE3A PDE3A KCNJ8 KCNJ8 PLCB3 PLCB3 EDNRA EDNRA KCNMB2 KCNMB2 GUCY1A1 GUCY1A1 PPP1CA PPP1CA ATF6B ATF6B KNG1 KNG1 RHOA RHOA GNAI2 GNAI2 TRPC6 TRPC6 GUCY1A2 GUCY1A2 VDAC1 VDAC1 CACNA1F CACNA1F PRKG2 PRKG2 PIK3CG PIK3CG PDE5A PDE5A GNAI1 GNAI1 MYLK2 MYLK2 ATP1B2 ATP1B2 NPPB NPPB OPRD1 OPRD1 PIK3R5 PIK3R5 MYLK4 MYLK4 ADCY2 ADCY2 PRKG1 PRKG1 KCNU1 KCNU1 VDAC3 VDAC3 CALML4 CALML4 ATP1A3 ATP1A3 INS-IGF2 INS-IGF2 SLC25A31 SLC25A31 CREB3L2 CREB3L2 PLCB1 PLCB1 PLCB4 PLCB4 SLC25A5 SLC25A5 GNA13 GNA13 ATP1B1 ATP1B1 ATP1B4 ATP1B4 GATA4 GATA4 ATF4 ATF4 PPP1CB PPP1CB PPP3CC PPP3CC EDNRB EDNRB PRKCE PRKCE CNGA1 CNGA1 PDE3B PDE3B RGS2 RGS2 ADORA1 ADORA1 ATP2B4 ATP2B4 IRS4 IRS4 ADRA2C ADRA2C ADRB1 ADRB1 ADRB3 ADRB3 AKT3 AKT3 RAF1 RAF1 KCNMB4 KCNMB4 MEF2A MEF2A PPP3R1 PPP3R1 PPP3CB PPP3CB MAPK1 MAPK1 GNA12 GNA12 CALML3 CALML3 GUCY1B1 GUCY1B1 AKT1 AKT1 ATP2B1 ATP2B1 PLN PLN PPIF PPIF CALM1 CALM1 KCNMA1 KCNMA1 SLC8A1 SLC8A1 ATP2A3 ATP2A3 PPP3CA PPP3CA TMIGD3 TMIGD3 KCNMB3 KCNMB3 PPP1R12A PPP1R12A ATP1A1 ATP1A1 ATF2 ATF2 ITPR2 ITPR2 MYL9 MYL9 IRS1 IRS1 NFATC2 NFATC2 ROCK2 ROCK2 MAP2K1 MAP2K1 MEF2D MEF2D ADRA2B ADRA2B BAD BAD ATP1B3 ATP1B3 ADCY8 ADCY8 ATP2A1 ATP2A1 VDAC2 VDAC2 NFATC1 NFATC1 GNAI3 GNAI3 AGTR1 AGTR1 ADRA1A ADRA1A ROCK1 ROCK1 CACNA1D CACNA1D NFATC3 NFATC3 ATP2A2 ATP2A2 IRS2 IRS2 SLC8A3 SLC8A3 ADCY1 ADCY1 ATP1A2 ATP1A2 ADCY5 ADCY5 SLC25A4 SLC25A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (386 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
GNAQG protein subunit alpha q. (358 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
LOC100600502Guanylate cyclase domain-containing protein. (613 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
SRFSerum response factor. (508 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PDE3APhosphodiesterase. (1141 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
KNG1Kininogen 1. (644 aa)
RHOARas homolog family member A. (193 aa)
GNAI2G protein subunit alpha i2. (355 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
GUCY1A2Uncharacterized protein. (385 aa)
VDAC1Voltage dependent anion channel 1. (282 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PDE5APhosphodiesterase. (875 aa)
GNAI1G protein subunit alpha i1. (353 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
NPPBNatriuretic peptide B. (134 aa)
OPRD1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (265 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1152 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
CALML4Calmodulin like 4. (196 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (952 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
GNA13G protein subunit alpha 13. (373 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
GATA4GATA binding protein 4. (443 aa)
ATF4BZIP domain-containing protein. (351 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
PDE3BPhosphodiesterase. (791 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1241 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
ADRA2CG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ADRB1Adrenoceptor beta 1. (476 aa)
ADRB3G_PROTEIN_RECEP_F1_2 domain-containing protein. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
GNA12G protein subunit alpha 12. (381 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1289 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (987 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
TMIGD3Transmembrane and immunoglobulin domain containing 3; Belongs to the G-protein coupled receptor 1 family. (347 aa)
KCNMB3Uncharacterized protein. (329 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
MYL9Myosin light chain 9. (172 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
ADRA2BG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
BADUncharacterized protein. (82 aa)
ATP1B3Uncharacterized protein. (89 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1031 aa)
VDAC2Voltage dependent anion channel 2. (297 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
GNAI3G protein subunit alpha i3. (354 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
SLC25A4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (366 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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