STRINGSTRING
CRKL CRKL GNB1 GNB1 CRK CRK ADCY3 ADCY3 CXCR3 CXCR3 LYN LYN CCL7 CCL7 CCL11 CCL11 CCL8 CCL8 CCL13 CCL13 CCL1 CCL1 BRAF BRAF ELMO1 ELMO1 GNG8 GNG8 CX3CL1 CX3CL1 CCL17 CCL17 GNAQ GNAQ GNGT2 GNGT2 TIAM1 TIAM1 ITK ITK RAP1A RAP1A GNG3 GNG3 PIK3CB PIK3CB GRK7 GRK7 CCL21 CCL21 PLCB3 PLCB3 DOCK2 DOCK2 KRAS KRAS PIK3CA PIK3CA GNB4 GNB4 LOC100580385 LOC100580385 PIK3R2 PIK3R2 XCR1 XCR1 CCR1 CCR1 GRK2 GRK2 RHOA RHOA GNAI2 GNAI2 PRKCD PRKCD LOC100580192 LOC100580192 WAS WAS CXCL6 CXCL6 PF4V1 PF4V1 PPBP PPBP CXCL5 CXCL5 CXCL3 CXCL3 CXCL2 CXCL2 CXCL11 CXCL11 CXCL9 CXCL9 CXCL10 CXCL10 CXCL13 CXCL13 CXCL14 CXCL14 HRAS HRAS CCL26 CCL26 PIK3CG PIK3CG JAK2 JAK2 GNAI1 GNAI1 HCK HCK GNG5 GNG5 PIK3R5 PIK3R5 CCL28 CCL28 CCL27 CCL27 ADCY2 ADCY2 STAT3 STAT3 SHC1 SHC1 CCR10 CCR10 SOS2 SOS2 IKBKB IKBKB CCR2 CCR2 NFKB1 NFKB1 CCL5 CCL5 CCL16 CCL16 CCL15 CCL15 CCL23 CCL23 CCL18 CCL18 LOC100602388 LOC100602388 PLCB1 PLCB1 CCL4 CCL4 IKBKG IKBKG PLCB4 PLCB4 GNGT1 GNGT1 GNG11 GNG11 SOS1 SOS1 GRK5 GRK5 ARRB1 ARRB1 ARRB2 ARRB2 CCR4 CCR4 FOXO3 FOXO3 AKT3 AKT3 M3ZB92_NOMLE M3ZB92_NOMLE RAF1 RAF1 CHUK CHUK STAT2 STAT2 GNG13 GNG13 GSK3B GSK3B GNG4 GNG4 MAPK1 MAPK1 AKT1 AKT1 CCL25 CCL25 LOC100586578 LOC100586578 PARD3 PARD3 ENSNLEP00000028912 ENSNLEP00000028912 PRKACB PRKACB INSL3 INSL3 LOC100583930 LOC100583930 GNG2 GNG2 GNB5 GNB5 PIK3R1 PIK3R1 CXCL16 CXCL16 ROCK2 ROCK2 CCL20 CCL20 SHC3 SHC3 MAP2K1 MAP2K1 CXCR5 CXCR5 RELA RELA RASGRP2 RASGRP2 CXCR4 CXCR4 BAD BAD ADCY8 ADCY8 CXCL12 CXCL12 PAK1 PAK1 GNG12 GNG12 GNG7 GNG7 CCL22 CCL22 NRAS NRAS GRB2 GRB2 CDC42 CDC42 GNAI3 GNAI3 CCR6 CCR6 LOC100607085 LOC100607085 CX3CR1 CX3CR1 RAC2 RAC2 PF4 PF4 CCR9 CCR9 LOC100602058 LOC100602058 ROCK1 ROCK1 PRKCB PRKCB CCR7 CCR7 PIK3R3 PIK3R3 CXCL8 CXCL8 ADCY1 ADCY1 PXN PXN ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GNB1G protein subunit beta 1. (340 aa)
CRKUncharacterized protein. (252 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
LYNTyrosine-protein kinase. (512 aa)
CCL7C-C motif chemokine. (99 aa)
CCL11C-C motif chemokine. (97 aa)
CCL8C-C motif chemokine. (99 aa)
CCL13C-C motif chemokine. (98 aa)
CCL1C-C motif chemokine. (96 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
CCL17C-C motif chemokine. (94 aa)
GNAQG protein subunit alpha q. (358 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1561 aa)
ITKTyrosine-protein kinase. (621 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GNB4G protein subunit beta 4. (340 aa)
LOC100580385SCY domain-containing protein. (114 aa)
PIK3R2Uncharacterized protein. (727 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (589 aa)
RHOARas homolog family member A. (193 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
LOC100580192G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (351 aa)
WASWASP actin nucleation promoting factor. (502 aa)
CXCL6C-X-C motif chemokine. (114 aa)
PF4V1C-X-C motif chemokine. (101 aa)
PPBPC-X-C motif chemokine. (128 aa)
CXCL5C-X-C motif chemokine. (114 aa)
CXCL3C-X-C motif chemokine. (107 aa)
CXCL2C-X-C motif chemokine. (106 aa)
CXCL11C-X-C motif chemokine. (94 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL13C-X-C motif chemokine ligand 13. (109 aa)
CXCL14C-X-C motif chemokine ligand 14. (111 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CCL26C-C motif chemokine. (94 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
GNAI1G protein subunit alpha i1. (353 aa)
HCKTyrosine-protein kinase. (525 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
CCL28C-C motif chemokine. (127 aa)
CCL27C-C motif chemokine ligand 27. (112 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SHC1SHC adaptor protein 1. (542 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
CCR2C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (374 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CCL5C-C motif chemokine. (91 aa)
CCL16SCY domain-containing protein. (75 aa)
CCL15C-C motif chemokine. (113 aa)
CCL23C-C motif chemokine. (137 aa)
CCL18C-C motif chemokine. (89 aa)
LOC100602388C-C motif chemokine. (92 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CCL4C-C motif chemokine. (92 aa)
IKBKGNEMO domain-containing protein. (173 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
ARRB1Arrestin beta 1. (418 aa)
ARRB2Arrestin beta 2. (430 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
M3ZB92_NOMLEUncharacterized protein. (87 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
GNG13G protein subunit gamma 13. (67 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CCL25SCY domain-containing protein. (131 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PARD3Par-3 family cell polarity regulator. (1273 aa)
ENSNLEP00000028912SCY domain-containing protein. (203 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
INSL3Insulin like 3. (157 aa)
LOC100583930C-C motif chemokine. (151 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
GNB5G protein subunit beta 5. (357 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
CXCL16C-X-C motif chemokine ligand 16. (265 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
CCL20C-C motif chemokine. (96 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RASGRP2RAS guanyl releasing protein 2. (610 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
BADUncharacterized protein. (82 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCL22C-C motif chemokine. (93 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Cell division cycle 42. (191 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (377 aa)
LOC100607085SCY domain-containing protein. (114 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
RAC2Rac family small GTPase 2. (192 aa)
PF4C-X-C motif chemokine. (106 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
LOC100602058C-C motif chemokine. (92 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
PXNUncharacterized protein. (1078 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (24%) [HD]