STRINGSTRING
SYK SYK GADD45G GADD45G LYN LYN CCL13 CCL13 ZAP70 ZAP70 RELB RELB TRAF5 TRAF5 EDARADD EDARADD TRADD TRADD CCL21 CCL21 MYD88 MYD88 LTA LTA LBP LBP CFLAR CFLAR BIRC3 BIRC3 CXCL3 CXCL3 CXCL2 CXCL2 MALT1 MALT1 UBE2I UBE2I TRAF2 TRAF2 GADD45A GADD45A CD14 CD14 CSNK2A1 CSNK2A1 BCL2L1 BCL2L1 CARD11 CARD11 RIPK1 RIPK1 TICAM2 TICAM2 PRKCQ PRKCQ VCAM1 VCAM1 ICAM1 ICAM1 IKBKB IKBKB TICAM1 TICAM1 NFKB1 NFKB1 MAP3K7 MAP3K7 CCL4 CCL4 IKBKG IKBKG TNFAIP3 TNFAIP3 XIAP XIAP NFKB2 NFKB2 TAB1 TAB1 TAB2 TAB2 TNFSF14 TNFSF14 TRAF3 TRAF3 PLAU PLAU TRAF1 TRAF1 IRAK4 IRAK4 TRAF6 TRAF6 PTGS2 PTGS2 IL1R1 IL1R1 TNFSF11 TNFSF11 TLR4 TLR4 CHUK CHUK TNFRSF1A TNFRSF1A LY96 LY96 TNFSF13B TNFSF13B EDA2R EDA2R MAP3K14 MAP3K14 CYLD CYLD RELA RELA BCL2 BCL2 EDA EDA BIRC2 BIRC2 CXCL12 CXCL12 BCL10 BCL10 PRKCB PRKCB TIRAP TIRAP TRIM25 TRIM25 CD40LG CD40LG TAB3 TAB3 IL1B IL1B BCL2A1 BCL2A1 CXCL8 CXCL8 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYKTyrosine-protein kinase. (532 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
LYNTyrosine-protein kinase. (512 aa)
CCL13C-C motif chemokine. (98 aa)
ZAP70Tyrosine-protein kinase. (704 aa)
RELBRELB proto-oncogene, NF-kB subunit. (586 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
EDARADDEDAR associated death domain. (215 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
CCL21C-C motif chemokine ligand 21. (134 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
LBPLipopolysaccharide binding protein. (481 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
CXCL3C-X-C motif chemokine. (107 aa)
CXCL2C-X-C motif chemokine. (106 aa)
MALT1MALT1 paracaspase. (824 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (190 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
BCL2L1BCL2 like 1. (217 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CCL4C-C motif chemokine. (92 aa)
IKBKGNEMO domain-containing protein. (173 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFSF14Tumor necrosis factor ligand 1D; Belongs to the tumor necrosis factor family. (240 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PLAUPlasminogen activator, urokinase. (414 aa)
TRAF1TNF receptor-associated factor. (416 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
LY96Lymphocyte antigen 96. (160 aa)
TNFSF13BTumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (285 aa)
EDA2REctodysplasin A2 receptor. (318 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (939 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EDAUncharacterized protein. (145 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
BCL10CARD domain-containing protein. (319 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
TRIM25Tripartite motif containing 25. (630 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
BCL2A1Uncharacterized protein. (205 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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