STRINGSTRING
PRKCA PRKCA FLT1 FLT1 RPS6KB1 RPS6KB1 EDN1 EDN1 CYBB CYBB HK2 HK2 NOS2 NOS2 PFKL PFKL EGLN3 EGLN3 TIMP1 TIMP1 IFNG IFNG TF TF IFNGR2 IFNGR2 NOS3 NOS3 GAPDH GAPDH PIK3CB PIK3CB PDK1 PDK1 PIK3CA PIK3CA PIK3R2 PIK3R2 PRKCG PRKCG PDHB PDHB SERPINE1 SERPINE1 ENO1 ENO1 CREBBP CREBBP ARNT ARNT PFKP PFKP HKDC1 HKDC1 STAT3 STAT3 EPO EPO EIF4E1B EIF4E1B HK3 HK3 NFKB1 NFKB1 INS-IGF2 INS-IGF2 EGLN2 EGLN2 ANGPT2 ANGPT2 TEK TEK EGF EGF ALDOB ALDOB ENO3 ENO3 RPS6 RPS6 LDHAL6A LDHAL6A PFKM PFKM LOC100604447 LOC100604447 PDHA2 PDHA2 PGK2 PGK2 LDHAL6B LDHAL6B AKT3 AKT3 LDHB LDHB CDKN1B CDKN1B TLR4 TLR4 LOC100581475-2 LOC100581475-2 LOC100586354 LOC100586354 MAPK1 MAPK1 AKT1 AKT1 HK1 HK1 LDHC LDHC ELOC ELOC ENO4 ENO4 PIK3R1 PIK3R1 ELOB-2 ELOB-2 MTOR MTOR EGFR EGFR MAP2K1 MAP2K1 RBX1 RBX1 EGLN1 EGLN1 RELA RELA BCL2 BCL2 ENO2 ENO2 IFNGR1 IFNGR1 CUL2 CUL2 LOC100581166 LOC100581166 ANGPT1 ANGPT1 LOC100600765 LOC100600765 LDHA LDHA EIF4E-2 EIF4E-2 PRKCB PRKCB PFKFB3 PFKFB3 IGF1 IGF1 HMOX1 HMOX1 PIK3R3 PIK3R3 IL6 IL6 EIF4E2 EIF4E2 LOC100579290 LOC100579290 HIF1A HIF1A ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
EDN1Endothelin 1. (211 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
HK2Hexokinase 2. (917 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
PFKLPhosphofructokinase, liver type. (726 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
TIMP1NTR domain-containing protein. (166 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ENO1Enolase 1. (434 aa)
CREBBPCREB binding protein. (2442 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
PFKP6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (783 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
HK3Hexokinase 3. (806 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (407 aa)
ANGPT2Angiopoietin 2. (496 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
ENO3Enolase 3. (432 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (853 aa)
LOC100604447Ubiquitin-like domain-containing protein. (118 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
PGK2Phosphoglycerate kinase 2. (417 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
CDKN1BUncharacterized protein. (204 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
LOC100581475-2Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
LOC100586354L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (354 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
HK1Hexokinase 1. (881 aa)
LDHCLactate dehydrogenase C. (331 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (96 aa)
ENO4Enolase 4. (628 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ELOB-2Ubiquitin-like domain-containing protein. (142 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RBX1Ring-box 1. (108 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (416 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENO2Enolase 2. (434 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
CUL2Uncharacterized protein. (90 aa)
LOC100581166Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
ANGPT1Angiopoietin 1. (498 aa)
LOC10060076540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (250 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
EIF4E-2Uncharacterized protein. (77 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (543 aa)
IGF1IlGF domain-containing protein. (196 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
IL6Uncharacterized protein. (258 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
LOC100579290Uncharacterized protein; Belongs to the LDH/MDH superfamily. (370 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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