57 items (Nomascus leucogenys) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Predicted Interactions

gene neighborhood

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Your Input:
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	TP53I3	Tumor protein p53 inducible protein 3. (346 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	CCNB1	Cyclin B1; Belongs to the cyclin family. (429 aa)
	CCNG1	Cyclin G1; Belongs to the cyclin family. (295 aa)
	BAX	Uncharacterized protein. (194 aa)
	ZMAT3	Zinc finger matrin-type 3. (289 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (402 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (426 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (344 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (402 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	BCL2L1	BCL2 like 1. (217 aa)
	STEAP3	STEAP3 metalloreductase. (498 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (398 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	FAS	Fas cell surface death receptor. (335 aa)
	SESN1	Sestrin 1. (551 aa)
	CYCS	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	GORAB	Golgin, RAB6 interacting. (394 aa)
	COP1	COP1 E3 ubiquitin ligase. (731 aa)
	GTSE1	G2 and S-phase expressed 1. (733 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (471 aa)
	SIVA1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	RPRM	Reprimo, TP53 dependent G2 arrest mediator homolog. (109 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	SESN2	Sestrin 2. (470 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2620 aa)
	CD82	Tetraspanin. (267 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	LOC100600457	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (261 aa)
	SERPINB5	Serpin family B member 5; Belongs to the serpin family. (375 aa)
	SIAH1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	TP53AIP1	Tumor protein p53 regulated apoptosis inducing protein 1. (123 aa)
	LOC100598207	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LOC101179576	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (355 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (159 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (448 aa)
	EI24	EI24 autophagy associated transmembrane protein. (340 aa)
	ENSNLEP00000038814	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
	TSC2	TSC complex subunit 2. (1777 aa)
	CHEK1	Checkpoint kinase 1. (492 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (538 aa)
	CCND3	Uncharacterized protein; Belongs to the cyclin family. (242 aa)
	SHISA5	Shisa family member 5. (245 aa)
	THBS1	Thrombospondin 1. (1173 aa)
	IGF1	IlGF domain-containing protein. (196 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAX	ENSNLEP00000007362	ENSNLEP00000005703	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.618
APAF1	BCL2	ENSNLEP00000007362	ENSNLEP00000036597	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.924
APAF1	BCL2L1	ENSNLEP00000007362	ENSNLEP00000011718	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 like 1.	0.899
APAF1	BID	ENSNLEP00000007362	ENSNLEP00000036929	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.456
APAF1	CASP3	ENSNLEP00000007362	ENSNLEP00000013240	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.996
APAF1	CASP8	ENSNLEP00000007362	ENSNLEP00000040588	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.918
APAF1	CASP9	ENSNLEP00000007362	ENSNLEP00000009264	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSNLEP00000007362	ENSNLEP00000018131	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	ENSNLEP00000038814	ENSNLEP00000007362	ENSNLEP00000038814	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.992
APAF1	FAS	ENSNLEP00000007362	ENSNLEP00000014908	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Fas cell surface death receptor.	0.459
APAF1	LOC100598207	ENSNLEP00000007362	ENSNLEP00000033823	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.992
APAF1	LOC100600457	ENSNLEP00000007362	ENSNLEP00000029749	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC101179576	ENSNLEP00000007362	ENSNLEP00000035365	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
APAF1	PTEN	ENSNLEP00000007362	ENSNLEP00000014741	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.503
APAF1	TNFRSF10A	ENSNLEP00000007362	ENSNLEP00000019277	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	TNF receptor superfamily member 10a.	0.513
ATR	CCNB1	ENSNLEP00000025629	ENSNLEP00000004906	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cyclin B1; Belongs to the cyclin family.	0.567
ATR	CCNB2	ENSNLEP00000025629	ENSNLEP00000014073	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cyclin B2; Belongs to the cyclin family.	0.567
ATR	CCNG1	ENSNLEP00000025629	ENSNLEP00000005653	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cyclin G1; Belongs to the cyclin family.	0.424
ATR	CCNG2	ENSNLEP00000025629	ENSNLEP00000009968	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cyclin G2; Belongs to the cyclin family.	0.424
ATR	CDK1	ENSNLEP00000025629	ENSNLEP00000028052	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.785

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