STRINGSTRING
ATG2B ATG2B EIF2S1 EIF2S1 RPS6KB1 RPS6KB1 HMGB1 HMGB1 IGBP1 IGBP1 RB1CC1 RB1CC1 SQSTM1 SQSTM1 TANK TANK WIPI1 WIPI1 PRAP1 PRAP1 ZFYVE1 ZFYVE1 DAPK3 DAPK3 EIF2AK3 EIF2AK3 MTMR3 MTMR3 ITPR1 ITPR1 MTMR14 MTMR14 MRAS MRAS PIK3CB PIK3CB RHEB RHEB DEPTOR DEPTOR KRAS KRAS DAPK1 DAPK1 ATG2A ATG2A AKT1S1 AKT1S1 CTSL CTSL PIK3CA PIK3CA PIK3R2 PIK3R2 CFLAR CFLAR PRKCD PRKCD MTMR4 MTMR4 HRAS HRAS ULK1 ULK1 ATG9A ATG9A LOC100592336 LOC100592336 BCL2L1 BCL2L1 TP53INP2 TP53INP2 PRKCQ PRKCQ RRAGC RRAGC BECN1 BECN1 PPP2CB PPP2CB PTEN PTEN WDR41 WDR41 ATG14 ATG14 TSC1 TSC1 RRAGD RRAGD ATG10 ATG10 ATG5 ATG5 MAP3K7 MAP3K7 INS-IGF2 INS-IGF2 AMBRA1 AMBRA1 SMCR8 SMCR8 ATG4A ATG4A RAB39B RAB39B PRKAA2 PRKAA2 ATG4C ATG4C ERN1 ERN1 DDIT4 DDIT4 TBK1 TBK1 RRAS2 RRAS2 ATG101 ATG101 TRAF6 TRAF6 LOC100595282 LOC100595282 IRS4 IRS4 RRAGA RRAGA ATG7 ATG7 AKT3 AKT3 RAF1 RAF1 DAPK2 DAPK2 RAB7A RAB7A SH3GLB1 SH3GLB1 MAPK10 MAPK10 LAMP1 LAMP1 MAPK1 MAPK1 AKT1 AKT1 PRKACB PRKACB PIK3C3 PIK3C3 ATG16L1 ATG16L1 UVRAG UVRAG MAPK9 MAPK9 BNIP3 BNIP3 ATG12 ATG12 PIK3R1 PIK3R1 GABARAPL1 GABARAPL1 GABARAP GABARAP MTOR MTOR PRKAA1 PRKAA1 ULK2 ULK2 IRS1 IRS1 GABARAPL2 GABARAPL2 MAP2K1 MAP2K1 ATG3 ATG3 PIK3R4 PIK3R4 EIF2AK4 EIF2AK4 BCL2 BCL2 MLST8 MLST8 CTSD CTSD BAD BAD TSC2 TSC2 SNAP29 SNAP29 NRAS NRAS ATG16L2 ATG16L2 PPP2CA PPP2CA VAMP8 VAMP8 CAMKK2 CAMKK2 RAB33B RAB33B RAB8A RAB8A PIK3R3 PIK3R3 MAPK8 MAPK8 IRS2 IRS2 LOC100605653 LOC100605653 RUBCN RUBCN STX17 STX17 HIF1A HIF1A VMP1 VMP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG2BAutophagy related 2B. (2072 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
HMGB1High mobility group box 1. (215 aa)
IGBP1Immunoglobulin binding protein 1. (338 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
SQSTM1UBA_5 domain-containing protein. (197 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (419 aa)
PRAP1Uncharacterized protein. (152 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (788 aa)
DAPK3Death associated protein kinase 3. (407 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1120 aa)
MTMR3Myotubularin related protein 3. (1083 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
MTMR14Myotubularin related protein 14. (650 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
DEPTORDEP domain containing MTOR interacting protein. (392 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
ATG2AAutophagy related 2A. (1881 aa)
AKT1S1AKT1 substrate 1. (276 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
MTMR4Myotubularin related protein 4. (1163 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (863 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
BCL2L1BCL2 like 1. (217 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
RRAGCRas related GTP binding C. (376 aa)
BECN1Beclin 1. (450 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
WDR41WD repeat domain 41. (459 aa)
ATG14Autophagy related 14. (492 aa)
TSC1TSC complex subunit 1. (1164 aa)
RRAGDRas related GTP binding D. (400 aa)
ATG10Autophagy related 10. (220 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1284 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
TBK1TANK binding kinase 1. (729 aa)
RRAS2RAS related 2. (204 aa)
ATG101Autophagy related 101. (218 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LOC100595282Uncharacterized protein. (287 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
RRAGARas related GTP binding A. (313 aa)
ATG7Autophagy related 7. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (370 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
LAMP1Lysosomal associated membrane protein 1. (416 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
ATG16L1Autophagy related 16 like 1. (600 aa)
UVRAGUV radiation resistance associated. (699 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
BNIP3Uncharacterized protein. (231 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (187 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1023 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ATG3Autophagy-related protein 3. (317 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1642 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (595 aa)
BADUncharacterized protein. (82 aa)
TSC2TSC complex subunit 2. (1777 aa)
SNAP29t-SNARE coiled-coil homology domain-containing protein. (258 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ATG16L2Autophagy related 16 like 2. (619 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (116 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
RAB8ARAB8A, member RAS oncogene family. (197 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
LOC100605653Uncharacterized protein. (796 aa)
RUBCNRubicon autophagy regulator. (966 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
VMP1Uncharacterized protein. (406 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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