STRINGSTRING
PRKCA PRKCA RPS6KB1 RPS6KB1 TBC1D7 TBC1D7 ATP6V1B2 ATP6V1B2 SLC38A9 SLC38A9 CLIP1 CLIP1 BRAF BRAF RPS6KA6 RPS6KA6 WNT5B WNT5B LRP6 LRP6 CASTOR1 CASTOR1 CAB39L CAB39L LAMTOR5 LAMTOR5 ATP6V1C1 ATP6V1C1 FZD6 FZD6 WNT2B WNT2B PIK3CB PIK3CB SEC13 SEC13 RHEB RHEB ATP6V1A ATP6V1A DEPDC5 DEPDC5 WNT3 WNT3 WNT9B WNT9B DEPTOR DEPTOR KRAS KRAS AKT1S1 AKT1S1 PIK3CA PIK3CA PIK3R2 PIK3R2 PRKCG PRKCG TTI1 TTI1 FNIP2 FNIP2 RHOA RHOA LPIN2 LPIN2 STRADB STRADB NPRL2 NPRL2 WNT5A WNT5A WNT4 WNT4 HRAS HRAS ULK1 ULK1 TELO2 TELO2 CASTOR2 CASTOR2 WNT6 WNT6 WNT10A WNT10A SEH1L SEH1L RPS6KA1 RPS6KA1 LOC100592336 LOC100592336 RPS6KA3 RPS6KA3 WNT2 WNT2 RRAGC RRAGC WNT16 WNT16 SOS2 SOS2 PTEN PTEN EIF4E1B EIF4E1B IKBKB IKBKB TSC1 TSC1 RRAGD RRAGD INS-IGF2 INS-IGF2 WNT7B WNT7B LAMTOR3 LAMTOR3 CAB39 CAB39 PRKAA2 PRKAA2 SGK1 SGK1 WNT8B WNT8B SKP2 SKP2 MIOS MIOS RICTOR RICTOR DDIT4 DDIT4 SOS1 SOS1 FZD3 FZD3 ATP6V1G1 ATP6V1G1 WNT11 WNT11 RPS6 RPS6 EIF4B EIF4B WNT1 WNT1 FZD9 FZD9 FZD10 FZD10 RRAGA RRAGA AKT3 AKT3 DVL3 DVL3 RAF1 RAF1 SESN2 SESN2 LPIN3 LPIN3 CHUK CHUK GSK3B GSK3B WNT3A WNT3A MAPK1 MAPK1 ATP6V1G2 ATP6V1G2 AKT1 AKT1 STRADA STRADA LPIN1 LPIN1 TNFRSF1A TNFRSF1A FZD7 FZD7 LAMTOR2 LAMTOR2 PIK3R1 PIK3R1 MTOR MTOR PRKAA1 PRKAA1 ULK2 ULK2 IRS1 IRS1 FZD4 FZD4 MAP2K1 MAP2K1 FNIP1 FNIP1 MLST8 MLST8 WNT8A WNT8A ATP6V1H ATP6V1H GRB10 GRB10 TSC2 TSC2 PRR5 PRR5 NRAS NRAS GRB2 GRB2 LOC100600765 LOC100600765 DVL1 DVL1 ATP6V1D ATP6V1D EIF4E-2 EIF4E-2 PRKCB PRKCB FZD2 FZD2 IGF1 IGF1 PIK3R3 PIK3R3 SLC7A5 SLC7A5 RNF152 RNF152 FZD5 FZD5 EIF4E2 EIF4E2 MAPKAP1 MAPKAP1 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (528 aa)
SLC38A9Solute carrier family 38 member 9. (561 aa)
CLIP1CAP-Gly domain containing linker protein 1. (1429 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
RPS6KA6Ribosomal protein S6 kinase. (738 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (346 aa)
CAB39LCalcium binding protein 39 like. (337 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (173 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
DEPDC5DEP domain-containing protein. (1602 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
DEPTORDEP domain containing MTOR interacting protein. (392 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TTI1TELO2 interacting protein 1. (1089 aa)
FNIP2Folliculin interacting protein 2. (1113 aa)
RHOARas homolog family member A. (193 aa)
LPIN2Lipin 2. (896 aa)
STRADBSTE20 related adaptor beta. (412 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
TELO2Telomere maintenance 2. (837 aa)
CASTOR2ACT_7 domain-containing protein. (169 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (360 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
RRAGCRas related GTP binding C. (376 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
TSC1TSC complex subunit 1. (1164 aa)
RRAGDRas related GTP binding D. (400 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
CAB39Calcium binding protein 39. (341 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SKP2S-phase kinase associated protein 2. (425 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1709 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
EIF4BEukaryotic translation initiation factor 4B. (612 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
RRAGARas related GTP binding A. (313 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
DVL3Dishevelled segment polarity protein 3. (673 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SESN2Sestrin 2. (470 aa)
LPIN3Lipin 3. (859 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
STRADASTE20 related adaptor alpha. (431 aa)
LPIN1Lipin 1. (975 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1023 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FNIP1Folliculin interacting protein 1. (1165 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
GRB10Growth factor receptor bound protein 10. (612 aa)
TSC2TSC complex subunit 2. (1777 aa)
PRR5Proline rich 5. (410 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC10060076540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (250 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
EIF4E-2Uncharacterized protein. (77 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
IGF1IlGF domain-containing protein. (196 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
RNF152Ring finger protein 152. (203 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
MAPKAP1MAPK associated protein 1. (523 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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