STRINGSTRING
GNB1 GNB1 ITGA2B ITGA2B PRKCA PRKCA FLT3 FLT3 SYK SYK TCL1A TCL1A FLT1 FLT1 RPS6KB1 RPS6KB1 FGF22 FGF22 COL9A1 COL9A1 RBL2 RBL2 FGF16 FGF16 IL2RG IL2RG THBS2 THBS2 LAMB3 LAMB3 PRL PRL COL6A5 COL6A5 COL6A6 COL6A6 BCL2L11 BCL2L11 FLT4 FLT4 GNG8 GNG8 GNGT2 GNGT2 FGF23 FGF23 FGF6 FGF6 NTF3 NTF3 CSF1 CSF1 VWF VWF CCNE2 CCNE2 OSM OSM PPP2R3C PPP2R3C NTRK2 NTRK2 PPP2R3A PPP2R3A NOS3 NOS3 GNG3 GNG3 CREB3 CREB3 PIK3CB PIK3CB LPAR5 LPAR5 RHEB RHEB PPP2R5D PPP2R5D FGF21 FGF21 YWHAH YWHAH GYS2 GYS2 VEGFB VEGFB NTF4 NTF4 KRAS KRAS KITLG KITLG MYC MYC G6PC3 G6PC3 PIK3CA PIK3CA GNB4 GNB4 PIK3R2 PIK3R2 COMP COMP FGF7 FGF7 ITGA4 ITGA4 HSP90B1 HSP90B1 ATF6B ATF6B YWHAB YWHAB LAMA3 LAMA3 LAMA1 LAMA1 PCK1 PCK1 ERBB4 ERBB4 FN1 FN1 CCNE1 CCNE1 CASP9 CASP9 EPHA2 EPHA2 COL4A1 COL4A1 EREG EREG PDGFA PDGFA HRAS HRAS KIT KIT LAMB4 LAMB4 FGF5 FGF5 LAMB1 LAMB1 PHLPP1 PHLPP1 PIK3CG PIK3CG JAK2 JAK2 COL1A1 COL1A1 RELN RELN VEGFD VEGFD LOC100592336 LOC100592336 IL2 IL2 IBSP IBSP BCL2L1 BCL2L1 FGF1 FGF1 MCL1 MCL1 GNG5 GNG5 COL9A3 COL9A3 LPAR3 LPAR3 PIK3R5 PIK3R5 TGFA TGFA PKN2 PKN2 CSF1R CSF1R PDGFRB PDGFRB THEM4 THEM4 FGF19 FGF19 ITGA1 ITGA1 COL6A3 COL6A3 EFNA5 EFNA5 CD19 CD19 CSF3R CSF3R IL2RA IL2RA IL4R IL4R PPP2R2C PPP2R2C G6PC G6PC EPO EPO PPP2CB PPP2CB SOS2 SOS2 PTEN PTEN COL9A2 COL9A2 FGFR1 FGFR1 ITGA8 ITGA8 EPOR EPOR EIF4E1B EIF4E1B LAMC3 LAMC3 F2R F2R IL3 IL3 FGFR4 FGFR4 IKBKB IKBKB TSC1 TSC1 LAMA4 LAMA4 FGF9 FGF9 ITGA11 ITGA11 COL4A4 COL4A4 NFKB1 NFKB1 INS-IGF2 INS-IGF2 YWHAQ YWHAQ PIK3AP1 PIK3AP1 CREB3L2 CREB3L2 PPP2R5E PPP2R5E IKBKG IKBKG MTCP1 MTCP1 PRKAA2 PRKAA2 SGK1 SGK1 FGF8 FGF8 ANGPT2 ANGPT2 JAK1 JAK1 PDGFB PDGFB ATF4 ATF4 FASLG FASLG LOC100580921-2 LOC100580921-2 TNN TNN TNR TNR GNGT1 GNGT1 GNG11 GNG11 COL1A2 COL1A2 IL7R IL7R TEK TEK OSMR OSMR DDIT4 DDIT4 SOS1 SOS1 EGF EGF VEGFC VEGFC TNC TNC FGFR2 FGFR2 CDK4 CDK4 LPAR1 LPAR1 RPS6 RPS6 PKN3 PKN3 ITGA5 ITGA5 ITGB7 ITGB7 EIF4B EIF4B NR4A1 NR4A1 BDNF BDNF COL2A1 COL2A1 LAMC1 LAMC1 TLR2 TLR2 G1SBE5_NOMLE G1SBE5_NOMLE IFNB1 IFNB1 LPAR4 LPAR4 SGK3 SGK3 FOXO3 FOXO3 MYB MYB AKT3 AKT3 HGF HGF CDK6 CDK6 RAF1 RAF1 COL4A6 COL4A6 CDKN1B CDKN1B LPAR6 LPAR6 MET MET EFNA3 EFNA3 PDGFD PDGFD LOC100585742 LOC100585742 TLR4 TLR4 CHUK CHUK FGF20 FGF20 HSP90AA1 HSP90AA1 GNG13 GNG13 ITGB6 ITGB6 GSK3B GSK3B GNG4 GNG4 EFNA1 EFNA1 SGK2 SGK2 LOC100595932 LOC100595932 IFNA6 IFNA6 CHRM1 CHRM1 MAPK1 MAPK1 AKT1 AKT1 LOC100586578 LOC100586578 YWHAZ YWHAZ FGF10 FGF10 CSF3 CSF3 IFNA8 IFNA8 NGF NGF INSL3 INSL3 IGF2 IGF2 CHRM2 CHRM2 LAMC2 LAMC2 GNG2 GNG2 ITGB1 ITGB1 PPP2R2D PPP2R2D GNB5 GNB5 CCND1 CCND1 PIK3R1 PIK3R1 PPP2R1B PPP2R1B ITGB3 ITGB3 PGF PGF ATF2 ATF2 MTOR MTOR PRKAA1 PRKAA1 LOC100582356 LOC100582356 IRS1 IRS1 EGFR EGFR PPP2R5A PPP2R5A MAP2K1 MAP2K1 LAMA2 LAMA2 RELA RELA BCL2 BCL2 G6PC2 G6PC2 PPP2R1A PPP2R1A MLST8 MLST8 PRLR PRLR ITGA6 ITGA6 FGF2 FGF2 COL4A5 COL4A5 CHAD CHAD BAD BAD EFNA2 EFNA2 TSC2 TSC2 GNG12 GNG12 GNG7 GNG7 ITGA10 ITGA10 FGF17 FGF17 PDGFC PDGFC AREG AREG PHLPP2 PHLPP2 NRAS NRAS GRB2 GRB2 IFNAR1 IFNAR1 ANGPT1 ANGPT1 CCND3 CCND3 IL7 IL7 PPP2CA PPP2CA PPP2R2A PPP2R2A LOC100600765 LOC100600765 EFNA4 EFNA4 BRCA1 BRCA1 ENSNLEP00000042279 ENSNLEP00000042279 ITGA2 ITGA2 IFNA5 IFNA5 YWHAE YWHAE EIF4E-2 EIF4E-2 THBS1 THBS1 KDR KDR PPP2R2B PPP2R2B IGF1 IGF1 LPAR2 LPAR2 PIK3R3 PIK3R3 ITGB5 ITGB5 ITGA9 ITGA9 GHR GHR COL4A3 COL4A3 IL6 IL6 NTRK1 NTRK1 ERBB3 ERBB3 EIF4E2 EIF4E2 LOC100603153 LOC100603153 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GNB1G protein subunit beta 1. (340 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1040 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
SYKTyrosine-protein kinase. (532 aa)
TCL1AT cell leukemia/lymphoma 1A. (114 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
RBL2RB transcriptional corepressor like 2. (1138 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
THBS2Thrombospondin 2. (1101 aa)
LAMB3Laminin subunit beta 3. (1137 aa)
PRLProlactin. (227 aa)
COL6A5Collagen type VI alpha 5 chain. (2590 aa)
COL6A6Collagen type VI alpha 6 chain. (2233 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
VWFVon Willebrand factor. (2790 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
OSMOncostatin M. (252 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (607 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3R2Uncharacterized protein. (727 aa)
COMPTSP C-terminal domain-containing protein. (194 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
LAMA3Laminin subunit alpha 3. (3316 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
FN1Fibronectin 1. (2477 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (402 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
EPHA2EPH receptor A2. (976 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
EREGEpiregulin. (169 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
LAMB4Laminin subunit beta 4. (1753 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
PHLPP1Uncharacterized protein. (1264 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
RELNReelin. (3460 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
BCL2L1BCL2 like 1. (217 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
COL9A3Uncharacterized protein. (589 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (342 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
TGFATransforming growth factor alpha. (166 aa)
PKN2Uncharacterized protein. (984 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
COL6A3Collagen type VI alpha 3 chain. (3149 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
CD19CD19 molecule. (558 aa)
CSF3RColony stimulating factor 3 receptor. (857 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
IL4RInterleukin 4 receptor. (810 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
COL9A2Collagen type IX alpha 2 chain. (661 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (520 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
LAMC3Laminin subunit gamma 3. (1550 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
TSC1TSC complex subunit 1. (1164 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (253 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa)
IKBKGNEMO domain-containing protein. (173 aa)
MTCP1Mature T cell proliferation 1. (107 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
ANGPT2Angiopoietin 2. (496 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
ATF4BZIP domain-containing protein. (351 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
LOC100580921-2Growth hormone B1. (217 aa)
TNNTenascin N. (1299 aa)
TNRTenascin R. (1348 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
IL7RInterleukin 7 receptor. (459 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
OSMROncostatin M receptor. (977 aa)
DDIT4DNA damage inducible transcript 4. (232 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
TNCTenascin C. (2207 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
PKN3Protein kinase N3. (895 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (799 aa)
EIF4BEukaryotic translation initiation factor 4B. (612 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (589 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
TLR2Toll-like receptor. (784 aa)
G1SBE5_NOMLEUncharacterized protein. (198 aa)
IFNB1Interferon beta 1. (187 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
FOXO3Forkhead box O3. (672 aa)
MYBMYB proto-oncogene, transcription factor. (744 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
CDKN1BUncharacterized protein. (204 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
EFNA3Ephrin A3; Belongs to the ephrin family. (238 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
LOC100585742Uncharacterized protein. (222 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
GNG13G protein subunit gamma 13. (67 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (204 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
LOC100595932Uncharacterized protein. (198 aa)
IFNA6Interferon alpha 6. (190 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF3Colony stimulating factor 3. (207 aa)
IFNA8Interferon alpha 8. (189 aa)
NGFNGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
INSL3Insulin like 3. (157 aa)
IGF2IlGF domain-containing protein. (180 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
LAMC2Laminin subunit gamma 2. (1178 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (444 aa)
GNB5G protein subunit beta 5. (357 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LOC100582356Uncharacterized protein. (217 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LAMA2Laminin subunit alpha 2. (3062 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (622 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
CHADChondroadherin. (363 aa)
BADUncharacterized protein. (82 aa)
EFNA2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (195 aa)
TSC2TSC complex subunit 2. (1777 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AREGEGF-like domain-containing protein. (274 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1317 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (557 aa)
ANGPT1Angiopoietin 1. (498 aa)
CCND3Uncharacterized protein; Belongs to the cyclin family. (242 aa)
IL7Interleukin 7. (179 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
LOC10060076540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (250 aa)
EFNA4Ephrin RBD domain-containing protein; Belongs to the ephrin family. (201 aa)
BRCA1BRCA1 DNA repair associated. (1884 aa)
ENSNLEP00000042279Uncharacterized protein. (587 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
IFNA5Interferon alpha 5. (189 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
EIF4E-2Uncharacterized protein. (77 aa)
THBS1Thrombospondin 1. (1173 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
IGF1IlGF domain-containing protein. (196 aa)
LPAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (297 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (859 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
GHRGrowth hormone receptor. (645 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
IL6Uncharacterized protein. (258 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
LOC100603153Uncharacterized protein. (445 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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