108 items (Nomascus leucogenys) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	BIRC5	Uncharacterized protein. (91 aa)
	HRK	Activator of apoptosis harakiri; Promotes apoptosis. (91 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (616 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1120 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (452 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
	TRADD	TNFRSF1A associated via death domain. (311 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
	BAX	Uncharacterized protein. (194 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (333 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
	CTSW	Cathepsin W; Belongs to the peptidase C1 family. (368 aa)
	PIK3R2	Uncharacterized protein. (727 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (603 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (426 aa)
	TUBA8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
	SEPTIN4	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (1010 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (335 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	TUBA4A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	LOC100592336	PH_3 domain-containing protein. (247 aa)
	DFFA	DNA fragmentation factor subunit alpha. (328 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	BCL2L1	BCL2 like 1. (217 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (331 aa)
	TUBA3E	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (459 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	LOC100585215	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	PARP2	Poly [ADP-ribose] polymerase. (583 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	TUBAL3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (587 aa)
	FAS	Fas cell surface death receptor. (335 aa)
	IL3	Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
	SPTA1	Spectrin alpha, erythrocytic 1. (2387 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	IKBKG	NEMO domain-containing protein. (173 aa)
	CSF2RB	Colony stimulating factor 2 receptor beta common subunit. (903 aa)
	CYCS	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (977 aa)
	ATF4	BZIP domain-containing protein. (351 aa)
	FASLG	Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	TNFRSF10A	TNF receptor superfamily member 10a. (471 aa)
	CTSC	Cathepsin C; Belongs to the peptidase C1 family. (462 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (335 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
	ENDOG	Endonuclease. (278 aa)
	TUBA1C	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (518 aa)
	ACTG1	Actin gamma 1. (378 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC100587604	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
	MAPK10	Mitogen-activated protein kinase. (550 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
	NGF	NGF domain-containing protein; Belongs to the NGF-beta family. (123 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	LOC100600457	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	CTSK	Cathepsin K; Belongs to the peptidase C1 family. (329 aa)
	DIABLO	Uncharacterized protein. (237 aa)
	MAPK9	Mitogen-activated protein kinase. (382 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (939 aa)
	LOC100604350	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
	PTPN13	Protein tyrosine phosphatase non-receptor type 13. (2492 aa)
	TP53AIP1	Tumor protein p53 regulated apoptosis inducing protein 1. (123 aa)
	LOC100598207	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
	LOC101179576	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
	BAK1	BCL2 antagonist/killer 1. (182 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
	CTSO	Cathepsin O; Belongs to the peptidase C1 family. (318 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (595 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (615 aa)
	BAD	Uncharacterized protein. (82 aa)
	ENSNLEP00000038814	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (538 aa)
	DAB2IP	DAB2 interacting protein. (1159 aa)
	BCL2A1	Uncharacterized protein. (205 aa)
	PIK3R3	Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (664 aa)
	NTRK1	Tyrosine-protein kinase receptor. (787 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1347 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTG1	CASP3	ENSNLEP00000023255	ENSNLEP00000013240	Actin gamma 1.	Caspase 3; Belongs to the peptidase C14A family.	0.916
ACTG1	CASP6	ENSNLEP00000023255	ENSNLEP00000020118	Actin gamma 1.	Caspase 6; Belongs to the peptidase C14A family.	0.911
ACTG1	LOC100585215	ENSNLEP00000023255	ENSNLEP00000012834	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.457
ACTG1	LOC100587604	ENSNLEP00000023255	ENSNLEP00000024125	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.457
ACTG1	LOC100604350	ENSNLEP00000023255	ENSNLEP00000032122	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.476
ACTG1	TUBA1C	ENSNLEP00000023255	ENSNLEP00000021663	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.543
ACTG1	TUBA3E	ENSNLEP00000023255	ENSNLEP00000012638	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.457
ACTG1	TUBA4A	ENSNLEP00000023255	ENSNLEP00000011349	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.460
ACTG1	TUBA8	ENSNLEP00000023255	ENSNLEP00000009611	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.478
ACTG1	TUBAL3	ENSNLEP00000023255	ENSNLEP00000013810	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.491
AIFM1	BAX	ENSNLEP00000018575	ENSNLEP00000005703	Apoptosis inducing factor mitochondria associated 1.	Uncharacterized protein.	0.915
AIFM1	CASP3	ENSNLEP00000018575	ENSNLEP00000013240	Apoptosis inducing factor mitochondria associated 1.	Caspase 3; Belongs to the peptidase C14A family.	0.454
AIFM1	CYCS	ENSNLEP00000018575	ENSNLEP00000018131	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.484
AIFM1	DIABLO	ENSNLEP00000018575	ENSNLEP00000030659	Apoptosis inducing factor mitochondria associated 1.	Uncharacterized protein.	0.403
AIFM1	ENDOG	ENSNLEP00000018575	ENSNLEP00000021379	Apoptosis inducing factor mitochondria associated 1.	Endonuclease.	0.758
AIFM1	ENSNLEP00000038814	ENSNLEP00000018575	ENSNLEP00000038814	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.484
AIFM1	LOC100598207	ENSNLEP00000018575	ENSNLEP00000033823	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.484
AIFM1	LOC100600457	ENSNLEP00000018575	ENSNLEP00000029749	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.484
AIFM1	LOC101179576	ENSNLEP00000018575	ENSNLEP00000035365	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.484
AKT1	AKT3	ENSNLEP00000028045	ENSNLEP00000023896	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.950

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