STRINGSTRING
PRKAB2 PRKAB2 PRKAB1 PRKAB1 RPS6KB1 RPS6KB1 RB1CC1 RB1CC1 ADCY3 ADCY3 KL KL FOXO1 FOXO1 ADIPOR2 ADIPOR2 CREB3 CREB3 PIK3CB PIK3CB RHEB RHEB BAX BAX KRAS KRAS AKT1S1 AKT1S1 PIK3CA PIK3CA PIK3R2 PIK3R2 ATF6B ATF6B ADIPOQ ADIPOQ HRAS HRAS ULK1 ULK1 PRKAG3 PRKAG3 SOD2 SOD2 CAMK4 CAMK4 ADCY2 ADCY2 SIRT1 SIRT1 SESN1 SESN1 EIF4E1B EIF4E1B TSC1 TSC1 ATG5 ATG5 NFKB1 NFKB1 INS-IGF2 INS-IGF2 CREB3L2 CREB3L2 PRKAA2 PRKAA2 ATF4 ATF4 ATG101 ATG101 CAT CAT IRS4 IRS4 FOXO3 FOXO3 AKT3 AKT3 SESN2 SESN2 AKT1 AKT1 PRKACB PRKACB PRKAG2 PRKAG2 PRKAG1 PRKAG1 PIK3R1 PIK3R1 ATF2 ATF2 MTOR MTOR PRKAA1 PRKAA1 IRS1 IRS1 RELA RELA PPARG PPARG ADCY8 ADCY8 TSC2 TSC2 NRAS NRAS PPARGC1A PPARGC1A CAMKK2 CAMKK2 EIF4E-2 EIF4E-2 IGF1 IGF1 PIK3R3 PIK3R3 IRS2 IRS2 ADIPOR1 ADIPOR1 ADCY1 ADCY1 EIF4E2 EIF4E2 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
KLKlotho. (855 aa)
FOXO1Forkhead box O1. (652 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
BAXUncharacterized protein. (194 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1049 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
SIRT1Sirtuin 1. (734 aa)
SESN1Sestrin 1. (551 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
TSC1TSC complex subunit 1. (1164 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ATF4BZIP domain-containing protein. (351 aa)
ATG101Autophagy related 101. (218 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SESN2Sestrin 2. (470 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
TSC2TSC complex subunit 2. (1777 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
EIF4E-2Uncharacterized protein. (77 aa)
IGF1IlGF domain-containing protein. (196 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ADIPOR1Adiponectin receptor 1. (369 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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