STRINGSTRING
PRKAB2 PRKAB2 PRKAB1 PRKAB1 RPS6KB1 RPS6KB1 ADCY3 ADCY3 FOXO1 FOXO1 HDAC1 HDAC1 SOD1 SOD1 PIK3CB PIK3CB KRAS KRAS AKT1S1 AKT1S1 PIK3CA PIK3CA PIK3R2 PIK3R2 HRAS HRAS PRKAG3 PRKAG3 SOD2 SOD2 ADCY2 ADCY2 SIRT1 SIRT1 ATG5 ATG5 INS-IGF2 INS-IGF2 PRKAA2 PRKAA2 EIF4EBP2 EIF4EBP2 CAT CAT IRS4 IRS4 HSPA6 HSPA6 FOXO3 FOXO3 AKT3 AKT3 AKT1 AKT1 PRKACB PRKACB PRKAG2 PRKAG2 PRKAG1 PRKAG1 CRYAB CRYAB PIK3R1 PIK3R1 MTOR MTOR PRKAA1 PRKAA1 IRS1 IRS1 HDAC2 HDAC2 ADCY8 ADCY8 NRAS NRAS HSPA8 HSPA8 IGF1 IGF1 PIK3R3 PIK3R3 IRS2 IRS2 ADCY1 ADCY1 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
FOXO1Forkhead box O1. (652 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT1S1AKT1 substrate 1. (276 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
SIRT1Sirtuin 1. (734 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
EIF4EBP2Uncharacterized protein. (120 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IGF1IlGF domain-containing protein. (196 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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