STRINGSTRING
GADD45G GADD45G MAPK12 MAPK12 RASSF5 RASSF5 MAPKAPK2 MAPKAPK2 ZFP36L1 ZFP36L1 RBL2 RBL2 FOXO1 FOXO1 SQSTM1 SQSTM1 MAP2K6 MAP2K6 E2F5 E2F5 RAD9B RAD9B RB1 RB1 CCNE2 CCNE2 ITPR1 ITPR1 CCNB1 CCNB1 TGFBR2 TGFBR2 MRAS MRAS E2F4 E2F4 PIK3CB PIK3CB RHEB RHEB LOC100592911 LOC100592911 KRAS KRAS MYC MYC PIK3CA PIK3CA PIK3R2 PIK3R2 LOC100579523 LOC100579523 RBL1 RBL1 TRPM7 TRPM7 RAD9A RAD9A PPP1CA PPP1CA CDC25A CDC25A PPID PPID ETS1 ETS1 CCNE1 CCNE1 VDAC1 VDAC1 CCNB3 CCNB3 SERPINE1 SERPINE1 HRAS HRAS E2F2 E2F2 MAPK13 MAPK13 GADD45A GADD45A CCNA2 CCNA2 E2F1 E2F1 LIN37 LIN37 CCNB2 CCNB2 SIRT1 SIRT1 PTEN PTEN RAD50 RAD50 VDAC3 VDAC3 TSC1 TSC1 CALML4 CALML4 NFKB1 NFKB1 SLC25A31 SLC25A31 TGFB1 TGFB1 HIPK4 HIPK4 RAD1 RAD1 BTRC BTRC SLC25A5 SLC25A5 GATA4 GATA4 PPP1CB PPP1CB PPP3CC PPP3CC CCNA1 CCNA1 LIN52 LIN52 MCU MCU TGFB3 TGFB3 ZFP36L2 ZFP36L2 CDK4 CDK4 RRAS2 RRAS2 HIPK3 HIPK3 SMAD2 SMAD2 FOXO3 FOXO3 AKT3 AKT3 CDK6 CDK6 RAF1 RAF1 MAPK14 MAPK14 ENSNLEP00000025590 ENSNLEP00000025590 ATR ATR LOC100584595 LOC100584595 PPP3R1 PPP3R1 PPP3CB PPP3CB MAPK1 MAPK1 CALML3 CALML3 AKT1 AKT1 CDK1 CDK1 CALM1 CALM1 ENSNLEP00000029648 ENSNLEP00000029648 NBN NBN MRE11 MRE11 PPP3CA PPP3CA CCND1 CCND1 PIK3R1 PIK3R1 MTOR MTOR ITPR2 ITPR2 NFATC2 NFATC2 LIN9 LIN9 MAP2K1 MAP2K1 RELA RELA CDKN2A CDKN2A MYBL2 MYBL2 VDAC2 VDAC2 TSC2 TSC2 RBBP4 RBBP4 HIPK2 HIPK2 NFATC1 NFATC1 CHEK1 CHEK1 NRAS NRAS TGFBR1 TGFBR1 CCND3 CCND3 SMAD3 SMAD3 E2F3 E2F3 LIN54 LIN54 CACNA1D CACNA1D NFATC3 NFATC3 PIK3R3 PIK3R3 CXCL8 CXCL8 IL6 IL6 CDKN2B CDKN2B SLC25A4 SLC25A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
RASSF5Ras association domain family member 5. (418 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
RBL2RB transcriptional corepressor like 2. (1138 aa)
FOXO1Forkhead box O1. (652 aa)
SQSTM1UBA_5 domain-containing protein. (197 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
E2F5E2F transcription factor 5. (346 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa)
RB1RB transcriptional corepressor 1. (919 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
E2F4E2F transcription factor 4. (397 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
LOC100592911Ig-like domain-containing protein; Belongs to the MHC class I family. (295 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
LOC100579523Major histocompatibility complex, class I, B; Belongs to the MHC class I family. (365 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1866 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (386 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CDC25ACell division cycle 25A. (524 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (402 aa)
VDAC1Voltage dependent anion channel 1. (282 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1395 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
E2F1E2F transcription factor 1. (391 aa)
LIN37Lin-37 DREAM MuvB core complex component. (246 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
SIRT1Sirtuin 1. (734 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
TSC1TSC complex subunit 1. (1164 aa)
CALML4Calmodulin like 4. (196 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
HIPK4Homeodomain interacting protein kinase 4. (564 aa)
RAD1RAD1 checkpoint DNA exonuclease. (283 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
GATA4GATA binding protein 4. (443 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
MCUMitochondrial calcium uniporter. (352 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ZFP36L2ZFP36 ring finger protein like 2. (495 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RRAS2RAS related 2. (204 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
ENSNLEP00000025590Ig-like domain-containing protein; Belongs to the MHC class I family. (340 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2620 aa)
LOC100584595WD_REPEATS_REGION domain-containing protein. (408 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
ENSNLEP00000029648Ig-like domain-containing protein; Belongs to the MHC class I family. (411 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
LIN9Lin-9 DREAM MuvB core complex component. (615 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
MYBL2MYB proto-oncogene like 2. (701 aa)
VDAC2Voltage dependent anion channel 2. (297 aa)
TSC2TSC complex subunit 2. (1777 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (410 aa)
HIPK2Homeodomain interacting protein kinase 2. (1198 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
CHEK1Checkpoint kinase 1. (492 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
CCND3Uncharacterized protein; Belongs to the cyclin family. (242 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
E2F3E2F transcription factor 3. (397 aa)
LIN54Lin-54 DREAM MuvB core complex component. (749 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IL6Uncharacterized protein. (258 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
SLC25A4Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (366 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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