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CACNG1 CACNG1 CACNG5 CACNG5 PRKCA PRKCA MYL2 MYL2 MAPK12 MAPK12 ADCY3 ADCY3 AGT AGT GNAQ GNAQ SCN7A SCN7A PPP2R3C PPP2R3C PPP2R3A PPP2R3A CREB3 CREB3 TPM2 TPM2 PPP2R5D PPP2R5D PLCB3 PLCB3 MYL4 MYL4 CACNG7 CACNG7 CACNG8 CACNG8 PPP1CA PPP1CA ATF6B ATF6B GNAI2 GNAI2 CACNA2D3 CACNA2D3 SCN4B SCN4B CACNA1F CACNA1F PIK3CG PIK3CG MAPK13 MAPK13 SLC9A1 SLC9A1 GNAI1 GNAI1 ATP1B2 ATP1B2 PIK3R5 PIK3R5 TNNI3 TNNI3 ACTC1 ACTC1 ADCY2 ADCY2 PPP2R2C PPP2R2C CACNG3 CACNG3 PPP2CB PPP2CB CALML4 CALML4 ATP1A3 ATP1A3 CREB3L2 CREB3L2 PPP2R5E PPP2R5E PLCB1 PLCB1 PLCB4 PLCB4 CACNG2 CACNG2 CACNA2D1 CACNA2D1 ATP1B1 ATP1B1 ATP1B4 ATP1B4 ATF4 ATF4 PPP1CB PPP1CB CACNB3 CACNB3 ATP2B4 ATP2B4 LOC101176289 LOC101176289 ADRB1 ADRB1 AKT3 AKT3 MAPK14 MAPK14 PPP1R1A PPP1R1A TNNT2 TNNT2 MAPK1 MAPK1 RPS6KA5 RPS6KA5 CALML3 CALML3 AKT1 AKT1 ATP2B1 ATP2B1 PLN PLN PRKACB PRKACB CACNB4 CACNB4 CALM1 CALM1 SLC8A1 SLC8A1 PPP2R2D PPP2R2D ATP2A3 ATP2A3 PPP2R1B PPP2R1B TPM1 TPM1 ATP1A1 ATP1A1 ATF2 ATF2 AGTR2 AGTR2 CACNG4 CACNG4 PPP2R5A PPP2R5A BCL2 BCL2 PPP2R1A PPP2R1A TPM3 TPM3 ATP1B3 ATP1B3 ADCY8 ADCY8 ATP2A1 ATP2A1 CACNA2D2 CACNA2D2 CACNA2D4 CACNA2D4 PPP2CA PPP2CA PPP2R2A PPP2R2A GNAI3 GNAI3 LOC100590514 LOC100590514 CACNB2 CACNB2 AGTR1 AGTR1 ADRA1A ADRA1A CACNA1D CACNA1D PPP2R2B PPP2R2B ATP2A2 ATP2A2 SCN5A SCN5A SLC8A3 SLC8A3 ADCY1 ADCY1 ATP1A2 ATP1A2 ADCY5 ADCY5 MYL3 MYL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MYL2Myosin light chain 2. (166 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
GNAQG protein subunit alpha q. (358 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1682 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1150 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (284 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (607 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MYL4Myosin light chain 4. (195 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (271 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (424 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (958 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
GNAI1G protein subunit alpha i1. (353 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CALML4Calmodulin like 4. (196 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (952 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1071 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
ATF4BZIP domain-containing protein. (351 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (444 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1241 aa)
LOC101176289Uncharacterized protein. (244 aa)
ADRB1Adrenoceptor beta 1. (476 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
PPP1R1AProtein phosphatase 1 regulatory inhibitor subunit 1A. (156 aa)
TNNT2Uncharacterized protein. (339 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (502 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (444 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (987 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (326 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
TPM3Uncharacterized protein; Belongs to the tropomyosin family. (285 aa)
ATP1B3Uncharacterized protein. (89 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1031 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1119 aa)
CACNA2D4VWFA domain-containing protein. (587 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
GNAI3G protein subunit alpha i3. (354 aa)
LOC100590514Uncharacterized protein. (130 aa)
CACNB2GuKc domain-containing protein. (586 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1925 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
MYL3EF-hand domain-containing protein. (161 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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