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PRKCA PRKCA AVPR1B AVPR1B EDN1 EDN1 ADCY3 ADCY3 AGT AGT BRAF BRAF PTGIR PTGIR GNAQ GNAQ ITPR1 ITPR1 LOC100600502 LOC100600502 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F RAMP3 RAMP3 PLA2G3 PLA2G3 PLCB3 PLCB3 EDNRA EDNRA KCNMB2 KCNMB2 PRKCG PRKCG GUCY1A1 GUCY1A1 PPP1CA PPP1CA CALCRL CALCRL RHOA RHOA GUCY1A2 GUCY1A2 PRKCD PRKCD AVP AVP PLA2G2E PLA2G2E PLA2G2A PLA2G2A PLA2G5 PLA2G5 PLA2G2D PLA2G2D CACNA1F CACNA1F MYLK2 MYLK2 NPPB NPPB MYH10 MYH10 MYLK4 MYLK4 ADCY2 ADCY2 PRKCQ PRKCQ PRKG1 PRKG1 KCNU1 KCNU1 EDN2 EDN2 ARHGEF11 ARHGEF11 CALD1 CALD1 CALML4 CALML4 PLCB1 PLCB1 PLCB4 PLCB4 MYH9 MYH9 ADORA2B ADORA2B GNA13 GNA13 PPP1CB PPP1CB ADORA2A ADORA2A PLA2G1B PLA2G1B PLA2G12B PLA2G12B PRKCE PRKCE PPP1R14A PPP1R14A AVPR1A AVPR1A ADM ADM PLA2G4A PLA2G4A LOC100592546 LOC100592546 LOC101176289 LOC101176289 RAF1 RAF1 KCNMB4 KCNMB4 RAMP1 RAMP1 ACTG2 ACTG2 MAPK1 MAPK1 GNA12 GNA12 CALML3 CALML3 GUCY1B1 GUCY1B1 PRKACB PRKACB CALM1 CALM1 PRKCH PRKCH KCNMA1 KCNMA1 CALCB CALCB KCNMB3 KCNMB3 PPP1R12A PPP1R12A ITPR2 ITPR2 MYL9 MYL9 ROCK2 ROCK2 MAP2K1 MAP2K1 ADCY8 ADCY8 EDN3 EDN3 ARHGEF12 ARHGEF12 AGTR1 AGTR1 ADRA1A ADRA1A ROCK1 ROCK1 PRKCB PRKCB CACNA1D CACNA1D PLA2G12A PLA2G12A ADCY1 ADCY1 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (426 aa)
EDN1Endothelin 1. (211 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (386 aa)
GNAQG protein subunit alpha q. (358 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
LOC100600502Guanylate cyclase domain-containing protein. (613 aa)
PLA2G4EPhospholipase A2. (867 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLA2G4FPhospholipase A2. (850 aa)
RAMP3Receptor activity modifying protein 3. (148 aa)
PLA2G3Phospholipase A2 group III. (509 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
RHOARas homolog family member A. (193 aa)
GUCY1A2Uncharacterized protein. (385 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
PLA2G2EPhospholipase A(2). (142 aa)
PLA2G2APhospholipase A(2). (144 aa)
PLA2G5Phospholipase A(2). (138 aa)
PLA2G2DPhospholipase A(2). (144 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
NPPBNatriuretic peptide B. (134 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1152 aa)
EDN2Endothelin 2. (177 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1557 aa)
CALD1Caldesmon 1. (751 aa)
CALML4Calmodulin like 4. (196 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
GNA13G protein subunit alpha 13. (373 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PLA2G1BPhospholipase A(2). (148 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PPP1R14AProtein phosphatase 1 regulatory inhibitor subunit 14A. (147 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (405 aa)
ADMAdrenomedullin. (184 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC100592546ANK_REP_REGION domain-containing protein. (515 aa)
LOC101176289Uncharacterized protein. (244 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
RAMP1Receptor activity modifying protein 1. (148 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
GNA12G protein subunit alpha 12. (381 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1289 aa)
CALCBCalcitonin related polypeptide beta. (127 aa)
KCNMB3Uncharacterized protein. (329 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
MYL9Myosin light chain 9. (172 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
EDN3Uncharacterized protein. (211 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
ADRA1AAdrenoceptor alpha 1A. (470 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
PLA2G12APhospholipase A2 group XIIA. (189 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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