STRINGSTRING
GNB1 GNB1 PRKAB2 PRKAB2 PRKAB1 PRKAB1 NOS1 NOS1 MYL2 MYL2 RPS6KB1 RPS6KB1 ADCY3 ADCY3 NOS2 NOS2 SPHK1 SPHK1 GNG8 GNG8 GNAQ GNAQ GNGT2 GNGT2 ITPR1 ITPR1 NOS3 NOS3 GNG3 GNG3 MRAS MRAS PLCB3 PLCB3 UCP1 UCP1 KRAS KRAS CDH1 CDH1 KLF2 KLF2 HDAC5 HDAC5 GNB4 GNB4 MYL4 MYL4 GNAI2 GNAI2 SERPINE1 SERPINE1 HRAS HRAS PIK3CG PIK3CG EGR1 EGR1 PRKAG3 PRKAG3 SLC9A1 SLC9A1 GNAI1 GNAI1 MYLK2 MYLK2 GNG5 GNG5 PIK3R5 PIK3R5 LIPE LIPE RYR3 RYR3 MYLK4 MYLK4 CAMK4 CAMK4 ADCY2 ADCY2 BECN1 BECN1 SMAD4 SMAD4 TFAM TFAM APLNR APLNR NRF1 NRF1 CALML4 CALML4 PLCB1 PLCB1 PLCB4 PLCB4 CCN2 CCN2 PRKAA2 PRKAA2 GNA13 GNA13 ADCY10 ADCY10 GNGT1 GNGT1 GNG11 GNG11 PRKCE PRKCE RPS6 RPS6 RRAS2 RRAS2 PDE3B PDE3B SMAD2 SMAD2 AKT3 AKT3 RAF1 RAF1 MEF2A MEF2A GNG13 GNG13 GNG4 GNG4 MAPK1 MAPK1 CALML3 CALML3 AKT1 AKT1 LOC100586578 LOC100586578 PLAT PLAT PRKACB PRKACB PIK3C3 PIK3C3 CALM1 CALM1 PRKAG2 PRKAG2 SLC8A1 SLC8A1 PRKAG1 PRKAG1 GNG2 GNG2 GNB5 GNB5 SPHK2 SPHK2 CCND1 CCND1 GABARAPL1 GABARAPL1 GABARAP GABARAP MTOR MTOR PRKAA1 PRKAA1 ITPR2 ITPR2 GABARAPL2 GABARAPL2 MAP2K1 MAP2K1 PIK3R4 PIK3R4 MEF2D MEF2D ADCY8 ADCY8 GNG12 GNG12 GNG7 GNG7 NRAS NRAS TGFBR1 TGFBR1 SMAD3 SMAD3 LOC100600765 LOC100600765 PPARGC1A PPARGC1A GNAI3 GNAI3 AGTR1 AGTR1 SLC8A3 SLC8A3 ADCY1 ADCY1 ADCY5 ADCY5 MYL3 MYL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNB1G protein subunit beta 1. (340 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
MYL2Myosin light chain 2. (166 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNAQG protein subunit alpha q. (358 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
KLF2Kruppel like factor 2. (355 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1154 aa)
GNB4G protein subunit beta 4. (340 aa)
MYL4Myosin light chain 4. (195 aa)
GNAI2G protein subunit alpha i2. (355 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
GNAI1G protein subunit alpha i1. (353 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
LIPELipase E, hormone sensitive type. (1072 aa)
RYR3Ryanodine receptor 3. (4794 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
BECN1Beclin 1. (450 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TFAMTranscription factor A, mitochondrial. (241 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
CALML4Calmodulin like 4. (196 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
CCN2Cellular communication network factor 2. (349 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GNA13G protein subunit alpha 13. (373 aa)
ADCY10Adenylate cyclase 10. (1518 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
RRAS2RAS related 2. (204 aa)
PDE3BPhosphodiesterase. (791 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (895 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
GNB5G protein subunit beta 5. (357 aa)
SPHK2Sphingosine kinase 2. (630 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
GABARAPL1GABA type A receptor associated protein like 1. (146 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC10060076540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (250 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
GNAI3G protein subunit alpha i3. (354 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
MYL3EF-hand domain-containing protein. (161 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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