STRINGSTRING
SYK SYK MAPK12 MAPK12 MAP2K7 MAP2K7 SQSTM1 SQSTM1 RELB RELB FOSB FOSB MAP2K6 MAP2K6 CSF1 CSF1 IFNG IFNG IFNGR2 IFNGR2 TGFBR2 TGFBR2 PIK3CB PIK3CB TNFRSF11B TNFRSF11B TREM2 TREM2 PIK3CA PIK3CA PIK3R2 PIK3R2 FOSL1 FOSL1 OSCAR OSCAR LILRA4 LILRA4 TRAF2 TRAF2 MAPK13 MAPK13 SIRPA SIRPA SIRPG SIRPG CSF1R CSF1R CAMK4 CAMK4 TYK2 TYK2 ACP5 ACP5 IKBKB IKBKB NFKB1 NFKB1 MAP3K7 MAP3K7 TGFB1 TGFB1 IKBKG IKBKG FCGR2A FCGR2A LOC101176357 LOC101176357 SPI1 SPI1 NFKB2 NFKB2 JAK1 JAK1 TAB1 TAB1 IRF9 IRF9 TAB2 TAB2 CALCR CALCR PPP3CC PPP3CC GAB2 GAB2 TEC TEC TRAF6 TRAF6 NCF2 NCF2 SOCS1 SOCS1 IFNB1 IFNB1 IL1R1 IL1R1 AKT3 AKT3 MAPK14 MAPK14 TNFSF11 TNFSF11 CHUK CHUK STAT2 STAT2 MAPK10 MAPK10 PPP3R1 PPP3R1 PPP3CB PPP3CB MAPK1 MAPK1 AKT1 AKT1 TNFRSF1A TNFRSF1A CTSK CTSK LOC100595088 LOC100595088 MAPK9 MAPK9 PPP3CA PPP3CA PIK3R1 PIK3R1 MAP3K14 MAP3K14 FOSL2 FOSL2 LILRB1 LILRB1 ITGB3 ITGB3 CYLD CYLD NFATC2 NFATC2 MAP2K1 MAP2K1 RELA RELA PPARG PPARG IFNGR1 IFNGR1 NFATC1 NFATC1 NOX1 NOX1 GRB2 GRB2 IFNAR1 IFNAR1 FHL2 FHL2 FYN FYN TGFBR1 TGFBR1 IL1B IL1B PIK3R3 PIK3R3 MAPK8 MAPK8 FOS FOS TNF TNF MITF MITF LCP2 LCP2 LOC100595279 LOC100595279
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYKTyrosine-protein kinase. (532 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
SQSTM1UBA_5 domain-containing protein. (197 aa)
RELBRELB proto-oncogene, NF-kB subunit. (586 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
TNFRSF11BTNF receptor superfamily member 11b. (428 aa)
TREM2Ig-like domain-containing protein. (222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
FOSL1BZIP domain-containing protein. (271 aa)
OSCARIg-like domain-containing protein. (266 aa)
LILRA4Leukocyte immunoglobulin like receptor A4. (499 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
SIRPAUncharacterized protein. (486 aa)
SIRPGSignal regulatory protein gamma. (354 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IKBKGNEMO domain-containing protein. (173 aa)
FCGR2AFc fragment of IgG receptor IIa. (317 aa)
LOC101176357Uncharacterized protein. (292 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IRF9Interferon regulatory factor 9. (392 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (509 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
GAB2GRB2 associated binding protein 2. (651 aa)
TECTyrosine-protein kinase. (631 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
SOCS1Suppressor of cytokine signaling 1. (208 aa)
IFNB1Interferon beta 1. (187 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
LOC100595088Uncharacterized protein. (398 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (939 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
LILRB1Uncharacterized protein. (493 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
NOX1NADPH oxidase 1. (564 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (557 aa)
FHL2Uncharacterized protein. (361 aa)
FYNTyrosine-protein kinase. (537 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
LOC100595279Uncharacterized protein. (212 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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