STRINGSTRING
CRKL CRKL ITGA2B ITGA2B PRKCA PRKCA MYL2 MYL2 DOCK1 DOCK1 FLT1 FLT1 CRK CRK COL9A1 COL9A1 THBS2 THBS2 PAK2 PAK2 LAMB3 LAMB3 COL6A5 COL6A5 COL6A6 COL6A6 BRAF BRAF FLT4 FLT4 PAK6 PAK6 ARHGAP35 ARHGAP35 ARHGAP5 ARHGAP5 VWF VWF CAV3 CAV3 RAP1A RAP1A PIK3CB PIK3CB VEGFB VEGFB PIK3CA PIK3CA CTNNB1 CTNNB1 PIK3R2 PIK3R2 COMP COMP PRKCG PRKCG ITGA4 ITGA4 PPP1CA PPP1CA LAMA3 LAMA3 RHOA RHOA MYL12A MYL12A LAMA1 LAMA1 BIRC3 BIRC3 FN1 FN1 FLNB FLNB COL4A1 COL4A1 PIP5K1B PIP5K1B PDGFA PDGFA MYL10 MYL10 HRAS HRAS LAMB4 LAMB4 LAMB1 LAMB1 COL1A1 COL1A1 RELN RELN VEGFD VEGFD LOC100592336 LOC100592336 IBSP IBSP MYLK2 MYLK2 COL9A3 COL9A3 PDGFRB PDGFRB ITGA1 ITGA1 MYLK4 MYLK4 COL6A3 COL6A3 CAV2 CAV2 SHC1 SHC1 TLN2 TLN2 SOS2 SOS2 PTEN PTEN COL9A2 COL9A2 ITGA8 ITGA8 LAMC3 LAMC3 LAMA4 LAMA4 ITGA11 ITGA11 COL4A4 COL4A4 FLNA FLNA PAK5 PAK5 PAK4 PAK4 XIAP XIAP PDGFB PDGFB PPP1CB PPP1CB TNN TNN TNR TNR COL1A2 COL1A2 PARVG PARVG SOS1 SOS1 EGF EGF VEGFC VEGFC TNC TNC ITGA5 ITGA5 PARVA PARVA ITGB7 ITGB7 COL2A1 COL2A1 LAMC1 LAMC1 LOC100592546 LOC100592546 ACTG1 ACTG1 AKT3 AKT3 HGF HGF RAF1 RAF1 COL4A6 COL4A6 MET MET PDGFD PDGFD PARVB PARVB ITGB6 ITGB6 MAPK10 MAPK10 GSK3B GSK3B MAPK1 MAPK1 AKT1 AKT1 ACTN4 ACTN4 LAMC2 LAMC2 ITGB1 ITGB1 MAPK9 MAPK9 CCND1 CCND1 PIK3R1 PIK3R1 CAV1 CAV1 ITGB3 ITGB3 PGF PGF PPP1R12A PPP1R12A MYL12B MYL12B TLN1 TLN1 MYL9 MYL9 ROCK2 ROCK2 EGFR EGFR SHC3 SHC3 MAP2K1 MAP2K1 LAMA2 LAMA2 BCL2 BCL2 ITGA6 ITGA6 COL4A5 COL4A5 CHAD CHAD BIRC2 BIRC2 BAD BAD PAK1 PAK1 ITGA10 ITGA10 PDGFC PDGFC GRB2 GRB2 CDC42 CDC42 FYN FYN CCND3 CCND3 PIP5K1A PIP5K1A ENSNLEP00000041829 ENSNLEP00000041829 RAC2 RAC2 ILK ILK ITGA2 ITGA2 ROCK1 ROCK1 PRKCB PRKCB THBS1 THBS1 KDR KDR IGF1 IGF1 PIK3R3 PIK3R3 ITGB5 ITGB5 MAPK8 MAPK8 ITGA9 ITGA9 ACTN1 ACTN1 COL4A3 COL4A3 PXN PXN ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1040 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MYL2Myosin light chain 2. (166 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
CRKUncharacterized protein. (252 aa)
COL9A1Collagen type IX alpha 1 chain. (921 aa)
THBS2Thrombospondin 2. (1101 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
LAMB3Laminin subunit beta 3. (1137 aa)
COL6A5Collagen type VI alpha 5 chain. (2590 aa)
COL6A6Collagen type VI alpha 6 chain. (2233 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
ARHGAP5Uncharacterized protein. (1502 aa)
VWFVon Willebrand factor. (2790 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R2Uncharacterized protein. (727 aa)
COMPTSP C-terminal domain-containing protein. (194 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LAMA3Laminin subunit alpha 3. (3316 aa)
RHOARas homolog family member A. (193 aa)
MYL12AMyosin light chain 12A. (177 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
FN1Fibronectin 1. (2477 aa)
FLNBFilamin B. (2585 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (572 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MYL10Myosin light chain 10. (226 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
LAMB4Laminin subunit beta 4. (1753 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
RELNReelin. (3460 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
IBSPIntegrin binding sialoprotein. (317 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
COL9A3Uncharacterized protein. (589 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
COL6A3Collagen type VI alpha 3 chain. (3149 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (86 aa)
SHC1SHC adaptor protein 1. (542 aa)
TLN2Uncharacterized protein. (2289 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
COL9A2Collagen type IX alpha 2 chain. (661 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
LAMC3Laminin subunit gamma 3. (1550 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
FLNAFilamin A. (2626 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
TNNTenascin N. (1299 aa)
TNRTenascin R. (1348 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
PARVGCalponin-homology (CH) domain-containing protein. (168 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
TNCTenascin C. (2207 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
PARVAParvin alpha. (345 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (799 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
LOC100592546ANK_REP_REGION domain-containing protein. (515 aa)
ACTG1Actin gamma 1. (378 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
PARVBParvin beta. (396 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ACTN4Actinin alpha 4. (931 aa)
LAMC2Laminin subunit gamma 2. (1178 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (225 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
MYL12BMyosin light chain 12B. (172 aa)
TLN1Talin 1. (2542 aa)
MYL9Myosin light chain 9. (172 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LAMA2Laminin subunit alpha 2. (3062 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
CHADChondroadherin. (363 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
BADUncharacterized protein. (82 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Cell division cycle 42. (191 aa)
FYNTyrosine-protein kinase. (537 aa)
CCND3Uncharacterized protein; Belongs to the cyclin family. (242 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSNLEP00000041829PIPK domain-containing protein. (329 aa)
RAC2Rac family small GTPase 2. (192 aa)
ILKIntegrin linked kinase. (458 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
THBS1Thrombospondin 1. (1173 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1367 aa)
IGF1IlGF domain-containing protein. (196 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (859 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
ACTN1Actinin alpha 1. (921 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
PXNUncharacterized protein. (1078 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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