STRINGSTRING
PRKAB2 PRKAB2 HCLS1 HCLS1 PRKAB1 PRKAB1 MSN MSN MYL2 MYL2 MPP5 MPP5 MAP2K7 MAP2K7 MAP3K1 MAP3K1 JAM2 JAM2 TJP3 TJP3 NF2 NF2 CLDN8 CLDN8 TIAM1 TIAM1 RAP1A RAP1A OCLN OCLN CLDN14 CLDN14 PARD6A PARD6A CLDN11 CLDN11 RAPGEF2 RAPGEF2 NEDD4 NEDD4 CGNL1 CGNL1 CLDN1 CLDN1 CLDN16 CLDN16 RHOA RHOA MYL12A MYL12A PARD6B PARD6B RDX RDX PCNA PCNA WAS WAS TUBA8 TUBA8 CLDN7 CLDN7 CLDN15 CLDN15 MICALL2 MICALL2 PRKAG3 PRKAG3 TUBA4A TUBA4A MYH10 MYH10 CGN CGN TUBA3E TUBA3E SLC9A3R1 SLC9A3R1 LOC100585215 LOC100585215 TUBAL3 TUBAL3 ACTR3 ACTR3 CFTR CFTR PPP2R2C PPP2R2C PPP2CB PPP2CB RAB8B RAB8B RAPGEF6 RAPGEF6 HSPA4 HSPA4 CD1D CD1D CD1A CD1A CD1C CD1C CD1B CD1B CD1E CD1E IGSF5 IGSF5 BVES BVES MYH9 MYH9 AMOT AMOT PRKAA2 PRKAA2 GATA4 GATA4 CLDN20 CLDN20 ACTR3B ACTR3B CLDN10 CLDN10 PRKCE PRKCE CDK4 CDK4 EPB41L4B EPB41L4B MPDZ MPDZ TUBA1C TUBA1C CLDN17 CLDN17 CLDN4 CLDN4 CLDN22 CLDN22 CLDN24 CLDN24 ACTG1 ACTG1 F11R F11R PRKCI PRKCI LOC100587604 LOC100587604 MAPK10 MAPK10 ARHGEF2 ARHGEF2 ACTR2 ACTR2 PARD3 PARD3 DLG1 DLG1 RAB13 RAB13 PRKACB PRKACB ARHGAP17 ARHGAP17 CLDN2 CLDN2 ACTN4 ACTN4 PRKAG2 PRKAG2 PRKAG1 PRKAG1 ITGB1 ITGB1 AMOTL1 AMOTL1 PPP2R2D PPP2R2D MAPK9 MAPK9 CCND1 CCND1 LOC100604350 LOC100604350 PPP2R1B PPP2R1B MYL12B MYL12B PRKAA1 PRKAA1 MYL9 MYL9 MPP4 MPP4 ROCK2 ROCK2 PPP2R1A PPP2R1A DLG2 DLG2 MARVELD2 MARVELD2 CDC42 CDC42 CRB3 CRB3 PPP2CA PPP2CA RUNX1 RUNX1 AMOTL2 AMOTL2 PPP2R2A PPP2R2A TJP1 TJP1 CLDN25 CLDN25 TJAP1 TJAP1 CLDN9 CLDN9 SYNPO SYNPO ROCK1 ROCK1 CLDN3 CLDN3 CACNA1D CACNA1D PPP2R2B PPP2R2B RAB8A RAB8A EZR EZR MAPK8 MAPK8 ACTN1 ACTN1 LOC101176801 LOC101176801 MAP3K5 MAP3K5 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
MSNMoesin. (566 aa)
MYL2Myosin light chain 2. (166 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1461 aa)
JAM2Junctional adhesion molecule 2. (312 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (863 aa)
NF2Neurofibromin 2. (595 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1561 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1642 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1319 aa)
CGNL1Cingulin like 1. (1302 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (305 aa)
RHOARas homolog family member A. (193 aa)
MYL12AMyosin light chain 12A. (177 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
RDXRadixin. (604 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
WASWASP actin nucleation promoting factor. (502 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
CLDN7Uncharacterized protein. (147 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
MICALL2MICAL like 2. (889 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
CGNCingulin. (1090 aa)
TUBA3ETubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (459 aa)
SLC9A3R1Uncharacterized protein. (276 aa)
LOC100585215Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (417 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
RAPGEF6Uncharacterized protein. (1609 aa)
HSPA4Heat shock protein family A (Hsp70) member 4. (830 aa)
CD1DCD1d molecule. (334 aa)
CD1ACD1a molecule. (327 aa)
CD1CCD1c molecule. (333 aa)
CD1BCD1b molecule. (333 aa)
CD1ECD1e molecule. (388 aa)
IGSF5Immunoglobulin superfamily member 5. (406 aa)
BVESBlood vessel epicardial substance. (360 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
AMOTAngiomotin. (1088 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GATA4GATA binding protein 4. (443 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (303 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (818 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2084 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (518 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
CLDN22Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
ACTG1Actin gamma 1. (378 aa)
F11RF11 receptor. (299 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
LOC100587604Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1031 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
PARD3Par-3 family cell polarity regulator. (1273 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
RAB13Uncharacterized protein. (203 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ARHGAP17Rho GTPase activating protein 17. (881 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
ACTN4Actinin alpha 4. (931 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
AMOTL1Angiomotin like 1. (962 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (444 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
LOC100604350Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (666 aa)
MYL12BMyosin light chain 12B. (172 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
MYL9Myosin light chain 9. (172 aa)
MPP4Membrane palmitoylated protein 4; Belongs to the MAGUK family. (609 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (588 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
MARVELD2MARVEL domain containing 2. (559 aa)
CDC42Cell division cycle 42. (191 aa)
CRB3Crumbs cell polarity complex component 3. (123 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (485 aa)
AMOTL2Angiomotin like 2. (780 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
CLDN25Claudin 25. (214 aa)
TJAP1Uncharacterized protein. (43 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
SYNPOUncharacterized protein. (195 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
RAB8ARAB8A, member RAS oncogene family. (197 aa)
EZREzrin. (586 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ACTN1Actinin alpha 1. (921 aa)
LOC101176801Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1347 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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