46 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	MAPK12	Mitogen-activated protein kinase. (368 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1461 aa)
	TKFC	Triokinase and FMN cyclase. (575 aa)
	AZI2	5-azacytidine induced 2. (392 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	TRADD	TNFRSF1A associated via death domain. (311 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (523 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	IRF7	Interferon regulatory factor 7. (524 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	IKBKG	NEMO domain-containing protein. (173 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	G1SBE5_NOMLE	Uncharacterized protein. (198 aa)
	IFNW1	Interferon omega 1. (201 aa)
	IFNB1	Interferon beta 1. (187 aa)
	IFIH1	Interferon induced with helicase C domain 1. (976 aa)
	MAPK14	Mitogen-activated protein kinase. (321 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
	MAPK10	Mitogen-activated protein kinase. (550 aa)
	LOC100595932	Uncharacterized protein. (198 aa)
	IFNA6	Interferon alpha 6. (190 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (704 aa)
	IFNA8	Interferon alpha 8. (189 aa)
	MAPK9	Mitogen-activated protein kinase. (382 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (187 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	OTUD5	OTU deubiquitinase 5. (542 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (538 aa)
	IFNA5	Interferon alpha 5. (189 aa)
	TRIM25	Tripartite motif containing 25. (630 aa)
	RNF125	Ring finger protein 125. (231 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSNLEP00000031895	ENSNLEP00000016123	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP8	ENSNLEP00000031895	ENSNLEP00000040588	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.683
ATG12	FADD	ENSNLEP00000031895	ENSNLEP00000012731	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.810
ATG12	IFIH1	ENSNLEP00000031895	ENSNLEP00000023306	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.858
ATG12	RIPK1	ENSNLEP00000031895	ENSNLEP00000013466	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Receptor interacting serine/threonine kinase 1.	0.471
ATG5	ATG12	ENSNLEP00000016123	ENSNLEP00000031895	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSNLEP00000016123	ENSNLEP00000008472	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.491
ATG5	CASP8	ENSNLEP00000016123	ENSNLEP00000040588	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.829
ATG5	FADD	ENSNLEP00000016123	ENSNLEP00000012731	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.874
ATG5	IFIH1	ENSNLEP00000016123	ENSNLEP00000023306	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.843
ATG5	RIPK1	ENSNLEP00000016123	ENSNLEP00000013466	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.706
ATG5	TBK1	ENSNLEP00000016123	ENSNLEP00000020707	Autophagy protein 5; Involved in autophagic vesicle formation.	TANK binding kinase 1.	0.420
AZI2	CHUK	ENSNLEP00000004965	ENSNLEP00000025468	5-azacytidine induced 2.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.560
AZI2	IKBKB	ENSNLEP00000004965	ENSNLEP00000015614	5-azacytidine induced 2.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.547
AZI2	IKBKG	ENSNLEP00000004965	ENSNLEP00000017384	5-azacytidine induced 2.	NEMO domain-containing protein.	0.946
AZI2	OTUD5	ENSNLEP00000004965	ENSNLEP00000037983	5-azacytidine induced 2.	OTU deubiquitinase 5.	0.456
AZI2	TANK	ENSNLEP00000004965	ENSNLEP00000002299	5-azacytidine induced 2.	TRAF family member associated NFKB activator.	0.934
AZI2	TBK1	ENSNLEP00000004965	ENSNLEP00000020707	5-azacytidine induced 2.	TANK binding kinase 1.	0.999
AZI2	TNF	ENSNLEP00000004965	ENSNLEP00000047690	5-azacytidine induced 2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.982
AZI2	TRAF3	ENSNLEP00000004965	ENSNLEP00000019474	5-azacytidine induced 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.586

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