STRINGSTRING
PTPN11 PTPN11 SYK SYK MAPK12 MAPK12 MAPKAPK2 MAPKAPK2 IL17D IL17D RELB RELB CLEC4D CLEC4D CLEC4E CLEC4E CCL17 CCL17 CLEC1B CLEC1B ITPR1 ITPR1 MRAS MRAS NLRP3 NLRP3 IL12B IL12B PIK3CB PIK3CB KRAS KRAS PIK3CA PIK3CA PIK3R2 PIK3R2 RHOA RHOA PRKCD PRKCD CARD9 CARD9 HRAS HRAS MALT1 MALT1 MAPK13 MAPK13 IL2 IL2 IRF1 IRF1 IKBKB IKBKB CALML4 CALML4 NFKB1 NFKB1 PLK3 PLK3 IKBKG IKBKG NFKB2 NFKB2 IRF9 IRF9 PPP3CC PPP3CC EGR3 EGR3 PYCARD PYCARD IL23A IL23A RRAS2 RRAS2 PTGS2 PTGS2 AKT3 AKT3 RAF1 RAF1 MAPK14 MAPK14 CHUK CHUK STAT2 STAT2 FCER1G FCER1G MAPK10 MAPK10 PPP3R1 PPP3R1 PPP3CB PPP3CB MAPK1 MAPK1 CALML3 CALML3 AKT1 AKT1 CALM1 CALM1 MAPK9 MAPK9 PPP3CA PPP3CA PIK3R1 PIK3R1 MAP3K14 MAP3K14 CYLD CYLD IL10 IL10 ITPR2 ITPR2 LOC100605369 LOC100605369 NFATC2 NFATC2 RELA RELA LOC100591293 LOC100591293 PAK1 PAK1 NFATC1 NFATC1 CCL22 CCL22 BCL3 BCL3 NRAS NRAS CASP8 CASP8 BCL10 BCL10 ARHGEF12 ARHGEF12 CASP1 CASP1 EGR2 EGR2 IL1B IL1B NFATC3 NFATC3 PIK3R3 PIK3R3 MAPK8 MAPK8 IL6 IL6 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
SYKTyrosine-protein kinase. (532 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
IL17DInterleukin 17D. (202 aa)
RELBRELB proto-oncogene, NF-kB subunit. (586 aa)
CLEC4DC-type lectin domain family 4 member D. (215 aa)
CLEC4EC-type lectin domain family 4 member E. (218 aa)
CCL17C-C motif chemokine. (94 aa)
CLEC1BC-type lectin domain family 1 member B. (229 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
NLRP3NLR family pyrin domain containing 3. (1020 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
RHOARas homolog family member A. (193 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CARD9Caspase recruitment domain family member 9. (536 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MALT1MALT1 paracaspase. (824 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IRF1Interferon regulatory factor. (324 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
CALML4Calmodulin like 4. (196 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PLK3Polo like kinase 3. (641 aa)
IKBKGNEMO domain-containing protein. (173 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
IRF9Interferon regulatory factor 9. (392 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
EGR3Early growth response 3. (387 aa)
PYCARDPYD and CARD domain containing. (195 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
RRAS2RAS related 2. (204 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
FCER1GUncharacterized protein. (112 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PPP3R1Uncharacterized protein. (189 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (939 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
IL10Interleukin 10. (178 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
LOC100605369Uncharacterized protein. (571 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LOC100591293Uncharacterized protein. (223 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
CCL22C-C motif chemokine. (93 aa)
BCL3BCL3 transcription coactivator. (453 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
BCL10CARD domain-containing protein. (319 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
EGR2Early growth response 2. (476 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL6Uncharacterized protein. (258 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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