STRINGSTRING
MAPK12 MAPK12 IL2RG IL2RG ZAP70 ZAP70 TBX21 TBX21 MAML1 MAML1 IFNG IFNG NFKBIE NFKBIE IFNGR2 IFNGR2 IL12B IL12B CD4 CD4 MAML3 MAML3 NOTCH2 NOTCH2 HLA-DRA HLA-DRA HLA-DQA2 HLA-DQA2 STAT4 STAT4 LOC100606816 LOC100606816 HLA-DPB1 HLA-DPB1 CD3G CD3G JAK2 JAK2 MAPK13 MAPK13 IL12RB2 IL12RB2 IL2 IL2 MAF MAF IL2RA IL2RA IL4R IL4R PRKCQ PRKCQ GATA3 GATA3 TYK2 TYK2 IL5 IL5 IKBKB IKBKB NFKB1 NFKB1 IKBKG IKBKG CD247 CD247 JAK1 JAK1 PPP3CC PPP3CC RBPJ RBPJ STAT6 STAT6 M3ZBW0_NOMLE M3ZBW0_NOMLE MAPK14 MAPK14 CHUK CHUK MAPK10 MAPK10 PPP3R1 PPP3R1 MAML2 MAML2 PPP3CB PPP3CB MAPK1 MAPK1 DLL1 DLL1 HLA-DPA1 HLA-DPA1 INSL3 INSL3 IL13 IL13 HLA-DQA1 HLA-DQA1 MAPK9 MAPK9 PPP3CA PPP3CA NFATC2 NFATC2 RELA RELA HLA-DMA HLA-DMA IFNGR1 IFNGR1 HLA-DOB HLA-DOB NFATC1 NFATC1 DLL3 DLL3 CD3E CD3E HLA-DQB1 HLA-DQB1 NFATC3 NFATC3 MAPK8 MAPK8 RUNX3 RUNX3 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (368 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
ZAP70Tyrosine-protein kinase. (704 aa)
TBX21Uncharacterized protein. (445 aa)
MAML1Mastermind like transcriptional coactivator 1. (1016 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NFKBIENFKB inhibitor epsilon. (487 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
CD4CD4 molecule. (458 aa)
MAML3Mastermind like transcriptional coactivator 3. (1133 aa)
NOTCH2Notch receptor 2. (2444 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
LOC100606816Ig-like domain-containing protein. (263 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
CD3GCD3g molecule. (182 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (862 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (401 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
IL4RInterleukin 4 receptor. (810 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
GATA3GATA binding protein 3. (444 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IKBKGNEMO domain-containing protein. (173 aa)
CD247CD247 molecule. (163 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (527 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PPP3R1Uncharacterized protein. (189 aa)
MAML2Uncharacterized protein. (593 aa)
PPP3CBSerine/threonine-protein phosphatase. (408 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
INSL3Insulin like 3. (157 aa)
IL13Interleukin 13. (146 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (255 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NFATC2Nuclear factor of activated T cells 2. (905 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (292 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
CD3ECD3e molecule. (198 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
NFATC3Nuclear factor of activated T cells 3. (1045 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (396 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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