STRINGSTRING
CRKL CRKL PRKCA PRKCA SYK SYK DOCK1 DOCK1 RPS6KB1 RPS6KB1 CRK CRK LYN LYN SPHK1 SPHK1 ARPC3 ARPC3 AMPH AMPH CFL2 CFL2 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F PIK3CB PIK3CB PIK3CA PIK3CA PIK3R2 PIK3R2 PRKCG PRKCG PRKCD PRKCD WAS WAS PIP5K1B PIP5K1B ASAP3 ASAP3 HCK HCK ARPC1A ARPC1A MYO10 MYO10 WASF1 WASF1 WASF3 WASF3 FCGR2A FCGR2A LOC101176357 LOC101176357 SCIN SCIN GAB2 GAB2 PRKCE PRKCE ARPC5L ARPC5L PLD2 PLD2 ARPC5 ARPC5 PLA2G4A PLA2G4A PTPRC PTPRC AKT3 AKT3 RAF1 RAF1 CFL1 CFL1 MAPK1 MAPK1 AKT1 AKT1 SPHK2 SPHK2 PIK3R1 PIK3R1 ARF6 ARF6 MAP2K1 MAP2K1 INPPL1 INPPL1 PAK1 PAK1 PLPP3 PLPP3 CDC42 CDC42 PIP5K1A PIP5K1A ENSNLEP00000041829 ENSNLEP00000041829 RAC2 RAC2 PLD1 PLD1 PRKCB PRKCB LIMK2 LIMK2 ASAP1 ASAP1 ARPC2 ARPC2 PIK3R3 PIK3R3 MARCKS MARCKS ARPC4 ARPC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
SYKTyrosine-protein kinase. (532 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
CRKUncharacterized protein. (252 aa)
LYNTyrosine-protein kinase. (512 aa)
SPHK1DAGKc domain-containing protein. (398 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (163 aa)
AMPHAmphiphysin. (695 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
PLA2G4EPhospholipase A2. (867 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLA2G4FPhospholipase A2. (850 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
WASWASP actin nucleation promoting factor. (502 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (572 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (903 aa)
HCKTyrosine-protein kinase. (525 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2031 aa)
WASF1WASP family member 1. (547 aa)
WASF3WASP family member 3. (502 aa)
FCGR2AFc fragment of IgG receptor IIa. (317 aa)
LOC101176357Uncharacterized protein. (292 aa)
SCINScinderin. (715 aa)
GAB2GRB2 associated binding protein 2. (651 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
PLD2Phospholipase. (933 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
PLA2G4APhospholipase A2. (749 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1304 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (197 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
SPHK2Sphingosine kinase 2. (630 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1256 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
PLPP3acidPPc domain-containing protein. (289 aa)
CDC42Cell division cycle 42. (191 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSNLEP00000041829PIPK domain-containing protein. (329 aa)
RAC2Rac family small GTPase 2. (192 aa)
PLD1Phospholipase. (1074 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LIMK2LIM domain kinase 2. (638 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1089 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (275 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (328 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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