STRINGSTRING
CRKL CRKL ITGA2B ITGA2B MSN MSN MYL2 MYL2 BDKRB2 BDKRB2 DOCK1 DOCK1 PIP4K2B PIP4K2B CRK CRK FGF22 FGF22 PFN4 PFN4 DIAPH2 DIAPH2 FGF16 FGF16 PAK2 PAK2 BRAF BRAF PAK6 PAK6 ARPC3 ARPC3 ARHGAP35 ARHGAP35 ARHGEF6 ARHGEF6 FGF23 FGF23 FGF6 FGF6 CFL2 CFL2 TIAM1 TIAM1 MRAS MRAS PIK3CB PIK3CB LPAR5 LPAR5 FGF21 FGF21 KRAS KRAS PIK3CA PIK3CA PIK3R2 PIK3R2 FGF7 FGF7 ITGA4 ITGA4 SSH3 SSH3 PPP1CA PPP1CA KNG1 KNG1 RHOA RHOA MYL12A MYL12A RDX RDX FN1 FN1 PIP5K1B PIP5K1B PDGFA PDGFA MYL10 MYL10 HRAS HRAS FGF5 FGF5 SLC9A1 SLC9A1 MYLK2 MYLK2 FGF1 FGF1 MYH10 MYH10 PDGFRB PDGFRB FGF19 FGF19 ITGA1 ITGA1 MYLK4 MYLK4 ARPC1A ARPC1A APC APC IQGAP1 IQGAP1 SOS2 SOS2 WASL WASL FGFR1 FGFR1 ITGA8 ITGA8 IQGAP2 IQGAP2 F2R F2R FGFR4 FGFR4 WASF1 WASF1 INSRR INSRR FGF9 FGF9 ITGA11 ITGA11 INS-IGF2 INS-IGF2 PAK5 PAK5 MYH9 MYH9 PAK4 PAK4 GNA13 GNA13 FGF8 FGF8 PDGFB PDGFB PPP1CB PPP1CB DIAPH3 DIAPH3 FGD1 FGD1 SCIN SCIN ITGAX ITGAX SOS1 SOS1 EGF EGF FGFR2 FGFR2 ITGAE ITGAE ARPC5L ARPC5L LPAR1 LPAR1 ITGA5 ITGA5 RRAS2 RRAS2 ITGB7 ITGB7 ARPC5 ARPC5 LOC100592546 LOC100592546 MOS MOS CHRM3 CHRM3 LPAR4 LPAR4 CHRM5 CHRM5 ACTG1 ACTG1 PIKFYVE PIKFYVE RAF1 RAF1 PDGFD PDGFD FGF20 FGF20 CFL1 CFL1 ITGB6 ITGB6 CHRM1 CHRM1 MAPK1 MAPK1 GNA12 GNA12 TMSB4X TMSB4X CYFIP2 CYFIP2 FGF10 FGF10 CYFIP1 CYFIP1 ACTN4 ACTN4 CHRM2 CHRM2 ITGB1 ITGB1 PIK3R1 PIK3R1 ITGB3 ITGB3 IQGAP3 IQGAP3 PPP1R12A PPP1R12A SSH1 SSH1 MYL12B MYL12B NCKAP1L NCKAP1L PFN3 PFN3 SSH2 SSH2 NCKAP1 NCKAP1 MYL9 MYL9 ROCK2 ROCK2 EGFR EGFR MAP2K1 MAP2K1 ITGA6 ITGA6 FGF2 FGF2 CXCR4 CXCR4 CXCL12 CXCL12 PAK1 PAK1 GNG12 GNG12 ITGA10 ITGA10 FGF17 FGF17 PDGFC PDGFC NRAS NRAS CDC42 CDC42 GIT1 GIT1 PIP5K1A PIP5K1A ENSNLEP00000041829 ENSNLEP00000041829 RAC2 RAC2 ARHGEF12 ARHGEF12 ITGA2 ITGA2 ROCK1 ROCK1 LIMK2 LIMK2 ARPC2 ARPC2 LPAR2 LPAR2 PIK3R3 PIK3R3 EZR EZR ITGB5 ITGB5 ARPC4 ARPC4 ITGA9 ITGA9 PFN1-2 PFN1-2 ACTN1 ACTN1 PXN PXN ENAH ENAH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1040 aa)
MSNMoesin. (566 aa)
MYL2Myosin light chain 2. (166 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (386 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
CRKUncharacterized protein. (252 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PFN4Profilin; Belongs to the profilin family. (128 aa)
DIAPH2Diaphanous related formin 2. (1102 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (163 aa)
ARHGAP35Rho GTPase activating protein 35. (1499 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1561 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (372 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
SSH3Slingshot protein phosphatase 3. (612 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
KNG1Kininogen 1. (644 aa)
RHOARas homolog family member A. (193 aa)
MYL12AMyosin light chain 12A. (177 aa)
RDXRadixin. (604 aa)
FN1Fibronectin 1. (2477 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (572 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MYL10Myosin light chain 10. (226 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (809 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (388 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1657 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
FGFR4Fibroblast growth factor receptor. (787 aa)
WASF1WASP family member 1. (547 aa)
INSRRTyrosine-protein kinase receptor. (1287 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
GNA13G protein subunit alpha 13. (373 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
DIAPH3Diaphanous related formin 3. (1147 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (962 aa)
SCINScinderin. (715 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1153 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1164 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
RRAS2RAS related 2. (204 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (799 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
LOC100592546ANK_REP_REGION domain-containing protein. (515 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (346 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
ACTG1Actin gamma 1. (378 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (197 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
GNA12G protein subunit alpha 12. (381 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1228 aa)
ACTN4Actinin alpha 4. (931 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (806 aa)
IQGAP3Uncharacterized protein. (2344 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
SSH1Slingshot protein phosphatase 1. (1032 aa)
MYL12BMyosin light chain 12B. (172 aa)
NCKAP1LNCK associated protein 1 like. (1109 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
NCKAP1NCK associated protein 1. (1134 aa)
MYL9Myosin light chain 9. (172 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CDC42Cell division cycle 42. (191 aa)
GIT1GIT ArfGAP 1. (772 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (562 aa)
ENSNLEP00000041829PIPK domain-containing protein. (329 aa)
RAC2Rac family small GTPase 2. (192 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1181 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa)
LIMK2LIM domain kinase 2. (638 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (275 aa)
LPAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (297 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
EZREzrin. (586 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (859 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
PFN1-2Profilin; Belongs to the profilin family. (128 aa)
ACTN1Actinin alpha 1. (921 aa)
PXNUncharacterized protein. (1078 aa)
ENAHWH1 domain-containing protein. (805 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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