STRINGSTRING
CRKL CRKL PRKAB2 PRKAB2 PRKAB1 PRKAB1 RPS6KB1 RPS6KB1 CRK CRK HK2 HK2 FOXO1 FOXO1 LOC100596750 LOC100596750 BRAF BRAF ACACA ACACA PIK3CB PIK3CB RHEB RHEB GYS2 GYS2 KRAS KRAS FLOT1 FLOT1 G6PC3 G6PC3 PIK3CA PIK3CA PIK3R2 PIK3R2 PPP1CA PPP1CA PCK1 PCK1 CBL CBL HRAS HRAS PRKAG3 PRKAG3 LOC100592336 LOC100592336 PHKA2 PHKA2 LIPE LIPE PPP1R3A PPP1R3A HKDC1 HKDC1 SHC1 SHC1 G6PC G6PC SOS2 SOS2 PYGL PYGL PPP1R3C PPP1R3C EIF4E1B EIF4E1B HK3 HK3 SOCS4 SOCS4 IKBKB IKBKB TSC1 TSC1 CALML4 CALML4 INS-IGF2 INS-IGF2 PRKAA2 PRKAA2 PPP1CB PPP1CB PHKB PHKB PHKG2 PHKG2 SOS1 SOS1 FBP2 FBP2 FBP1 FBP1 RPS6 RPS6 PDE3B PDE3B PPP1R3D PPP1R3D IRS4 IRS4 SOCS1 SOCS1 PRKCI PRKCI AKT3 AKT3 RAF1 RAF1 RHOQ RHOQ MAPK10 MAPK10 GSK3B GSK3B MAPK1 MAPK1 CALML3 CALML3 AKT1 AKT1 PRKACB PRKACB CALM1 CALM1 HK1 HK1 PHKA1 PHKA1 PRKAG2 PRKAG2 PRKAG1 PRKAG1 SREBF1 SREBF1 PPP1R3F PPP1R3F MAPK9 MAPK9 PRKAR2A PRKAR2A PIK3R1 PIK3R1 MTOR MTOR PRKAA1 PRKAA1 IRS1 IRS1 SHC3 SHC3 MAP2K1 MAP2K1 G6PC2 G6PC2 INPPL1 INPPL1 BAD BAD TSC2 TSC2 NRAS NRAS GRB2 GRB2 LOC100600765 LOC100600765 PPARGC1A PPARGC1A PPP1R3B PPP1R3B PRKAR1A PRKAR1A EIF4E-2 EIF4E-2 PIK3R3 PIK3R3 MAPK8 MAPK8 IRS2 IRS2 EIF4E2 EIF4E2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
CRKUncharacterized protein. (252 aa)
HK2Hexokinase 2. (917 aa)
FOXO1Forkhead box O1. (652 aa)
LOC100596750Carrier domain-containing protein. (2303 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
ACACAAcetyl-CoA carboxylase alpha. (2338 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
CBLCbl proto-oncogene. (905 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1181 aa)
LIPELipase E, hormone sensitive type. (1072 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1120 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
SHC1SHC adaptor protein 1. (542 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
HK3Hexokinase 3. (806 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
TSC1TSC complex subunit 1. (1164 aa)
CALML4Calmodulin like 4. (196 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1094 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (374 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (325 aa)
FBP1Fructose-bisphosphatase 1. (281 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
PDE3BPhosphodiesterase. (791 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
SOCS1Suppressor of cytokine signaling 1. (208 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
RHOQUncharacterized protein. (190 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
HK1Hexokinase 1. (881 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1240 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (798 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (404 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1256 aa)
BADUncharacterized protein. (82 aa)
TSC2TSC complex subunit 2. (1777 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC10060076540S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (250 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
EIF4E-2Uncharacterized protein. (77 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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