STRINGSTRING
PRKCA PRKCA PDX1 PDX1 ADCY3 ADCY3 GCG GCG GIP GIP GNAQ GNAQ CREB3 CREB3 PLCB3 PLCB3 SLC2A2 SLC2A2 KCNMB2 KCNMB2 CCK CCK RAB3A RAB3A PRKCG PRKCG ATF6B ATF6B ADCYAP1 ADCYAP1 CACNA1F CACNA1F ATP1B2 ATP1B2 VAMP2 VAMP2 GLP1R GLP1R ADCY2 ADCY2 KCNU1 KCNU1 ATP1A3 ATP1A3 INS-IGF2 INS-IGF2 CREB3L2 CREB3L2 PLCB1 PLCB1 PLCB4 PLCB4 SNAP25 SNAP25 ATP1B1 ATP1B1 ATP1B4 ATP1B4 ATF4 ATF4 CCKAR CCKAR LOC101176289 LOC101176289 GPR119 GPR119 CHRM3 CHRM3 KCNMB4 KCNMB4 KCNN2 KCNN2 PRKACB PRKACB KCNMA1 KCNMA1 KCNMB3 KCNMB3 KCNN1 KCNN1 ATP1A1 ATP1A1 ATF2 ATF2 ATP1B3 ATP1B3 ADCY8 ADCY8 PCLO PCLO PRKCB PRKCB KCNJ11 KCNJ11 CACNA1D CACNA1D ADCY1 ADCY1 ATP1A2 ATP1A2 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
GCGGlucagon. (180 aa)
GIPGastric inhibitory polypeptide. (153 aa)
GNAQG protein subunit alpha q. (358 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
CCKCholecystokinin. (115 aa)
RAB3ARAB3A, member RAS oncogene family. (186 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (1152 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (952 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
ATF4BZIP domain-containing protein. (351 aa)
CCKARCholecystokinin A receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
LOC101176289Uncharacterized protein. (244 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
KCNN2CaMBD domain-containing protein. (834 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1289 aa)
KCNMB3Uncharacterized protein. (329 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (543 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ATP1B3Uncharacterized protein. (89 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
PCLOUncharacterized protein. (1217 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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