STRINGSTRING
PRKCA PRKCA MAPK12 MAPK12 ADCY3 ADCY3 MAP2K7 MAP2K7 MMP2 MMP2 MAP3K1 MAP3K1 MAP2K6 MAP2K6 GNAQ GNAQ ITPR1 ITPR1 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F PLCB3 PLCB3 KRAS KRAS PRKCD PRKCD CACNA1F CACNA1F HRAS HRAS MAPK7 MAPK7 EGR1 EGR1 MAPK13 MAPK13 GNRHR GNRHR HBEGF HBEGF MAP3K4 MAP3K4 ADCY2 ADCY2 SOS2 SOS2 CALML4 CALML4 PLCB1 PLCB1 PLCB4 PLCB4 MMP14 MMP14 ATF4 ATF4 SOS1 SOS1 PLD2 PLD2 FSHB FSHB PLA2G4A PLA2G4A LOC101176289 LOC101176289 MAP3K2 MAP3K2 RAF1 RAF1 MAPK14 MAPK14 MAPK10 MAPK10 MAP2K4 MAP2K4 GNRH1 GNRH1 MAPK1 MAPK1 CALML3 CALML3 PRKACB PRKACB LHB LHB CALM1 CALM1 MAPK9 MAPK9 ITPR2 ITPR2 EGFR EGFR MAP2K1 MAP2K1 ADCY8 ADCY8 NRAS NRAS GRB2 GRB2 CDC42 CDC42 PLD1 PLD1 PRKCB PRKCB CACNA1D CACNA1D MAPK8 MAPK8 ADCY1 ADCY1 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1461 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
GNAQG protein subunit alpha q. (358 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
PLA2G4EPhospholipase A2. (867 aa)
PLA2G4DPhospholipase A2. (818 aa)
PLA2G4FPhospholipase A2. (850 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
GNRHRGonadotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1592 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML4Calmodulin like 4. (196 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
MMP14Matrix metallopeptidase 14. (586 aa)
ATF4BZIP domain-containing protein. (351 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
PLD2Phospholipase. (933 aa)
FSHBFollicle stimulating hormone beta subunit. (129 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC101176289Uncharacterized protein. (244 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (622 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
LHBCys_knot domain-containing protein. (116 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Cell division cycle 42. (191 aa)
PLD1Phospholipase. (1074 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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