STRINGSTRING
ADCY3 ADCY3 MMP2 MMP2 RARA RARA GNAO1 GNAO1 KRT24 KRT24 KRT25 KRT25 KRT10 KRT10 KRT26 KRT26 KRT27 KRT27 KRT12 KRT12 KRT20 KRT20 KRT39 KRT39 KRT40 KRT40 FKBP4 FKBP4 GNAQ GNAQ ITPR1 ITPR1 NOS3 NOS3 CREB3 CREB3 PIK3CB PIK3CB PLCB3 PLCB3 KRAS KRAS PIK3CA PIK3CA PIK3R2 PIK3R2 HSP90B1 HSP90B1 ATF6B ATF6B MMP9 MMP9 NCOA3 NCOA3 GNAI2 GNAI2 PGR PGR PRKCD PRKCD KCNJ5 KCNJ5 HRAS HRAS FKBP5 FKBP5 HBEGF HBEGF GNAI1 GNAI1 TGFA TGFA KRT33A KRT33A KRT33B KRT33B KRT31 KRT31 KRT34 KRT34 KRT37 KRT37 KRT32 KRT32 KRT35 KRT35 KRT36 KRT36 KRT13 KRT13 KRT15 KRT15 KRT19 KRT19 KRT9 KRT9 KRT14 KRT14 LOC100585005 LOC100585005 KRT16 KRT16 KRT17 KRT17 NCOA2 NCOA2 KCNJ3 KCNJ3 ADCY2 ADCY2 SHC1 SHC1 SOS2 SOS2 CALML4 CALML4 CREB3L2 CREB3L2 ESR2 ESR2 PLCB1 PLCB1 PLCB4 PLCB4 TFF1 TFF1 ATF4 ATF4 ESR1 ESR1 SOS1 SOS1 GABBR2 GABBR2 SP1 SP1 KRT18 KRT18 LOC101176289 LOC101176289 HSPA6 HSPA6 AKT3 AKT3 RAF1 RAF1 GPER1 GPER1 HSP90AA1 HSP90AA1 MAPK1 MAPK1 CALML3 CALML3 AKT1 AKT1 GRM1 GRM1 PRKACB PRKACB CALM1 CALM1 PIK3R1 PIK3R1 LOC100584684 LOC100584684 ATF2 ATF2 ITPR2 ITPR2 EGFR EGFR SHC3 SHC3 MAP2K1 MAP2K1 BCL2 BCL2 EBAG9 EBAG9 GABBR1 GABBR1 CTSD CTSD ADCY8 ADCY8 KRT38 KRT38 KCNJ9 KCNJ9 NRAS NRAS GRB2 GRB2 GNAI3 GNAI3 HSPA8 HSPA8 OPRM1 OPRM1 PIK3R3 PIK3R3 KCNJ6 KCNJ6 ADCY1 ADCY1 FOS FOS NCOA1 NCOA1 LOC100603153 LOC100603153 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
RARARetinoic acid receptor alpha. (458 aa)
GNAO1G protein subunit alpha o1. (353 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (516 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (566 aa)
KRT26Keratin 26; Belongs to the intermediate filament family. (468 aa)
KRT27Keratin 27; Belongs to the intermediate filament family. (460 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (495 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (424 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (491 aa)
KRT40Keratin 40; Belongs to the intermediate filament family. (431 aa)
FKBP4Peptidylprolyl isomerase. (424 aa)
GNAQG protein subunit alpha q. (358 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
HSP90B1Heat shock protein 90 beta family member 1. (804 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
NCOA3Nuclear receptor coactivator. (1419 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PGRUncharacterized protein. (339 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (418 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
GNAI1G protein subunit alpha i1. (353 aa)
TGFATransforming growth factor alpha. (166 aa)
KRT33AKeratin 33A; Belongs to the intermediate filament family. (404 aa)
KRT33BKeratin 33B; Belongs to the intermediate filament family. (404 aa)
KRT31Keratin 31; Belongs to the intermediate filament family. (416 aa)
KRT34Keratin 34; Belongs to the intermediate filament family. (454 aa)
KRT37Keratin 37; Belongs to the intermediate filament family. (449 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (448 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (417 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (450 aa)
KRT15Keratin 15; Belongs to the intermediate filament family. (437 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (400 aa)
KRT9IF rod domain-containing protein; Belongs to the intermediate filament family. (391 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (471 aa)
LOC100585005IF rod domain-containing protein; Belongs to the intermediate filament family. (379 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (476 aa)
KRT17IF rod domain-containing protein; Belongs to the intermediate filament family. (432 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
SHC1SHC adaptor protein 1. (542 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML4Calmodulin like 4. (196 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ESR2Estrogen receptor 2. (530 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
TFF1Trefoil factor 1. (84 aa)
ATF4BZIP domain-containing protein. (351 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
SP1Sp1 transcription factor. (786 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (430 aa)
LOC101176289Uncharacterized protein. (244 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (853 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
LOC100584684IF rod domain-containing protein; Belongs to the intermediate filament family. (401 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (258 aa)
GABBR1G_PROTEIN_RECEP_F3_4 domain-containing protein. (281 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (595 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
KRT38Keratin 38; Belongs to the intermediate filament family. (468 aa)
KCNJ9Uncharacterized protein. (322 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GNAI3G protein subunit alpha i3. (354 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
LOC100603153Uncharacterized protein. (445 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.