STRINGSTRING
PTPN11 PTPN11 PRKAB2 PRKAB2 PRKAB1 PRKAB1 ADIPOR2 ADIPOR2 NFKBIE NFKBIE TRADD TRADD AGRP AGRP G6PC3 G6PC3 ADIPOQ ADIPOQ RXRB RXRB PCK1 PCK1 TRAF2 TRAF2 JAK2 JAK2 PRKAG3 PRKAG3 ACSL3 ACSL3 STAT3 STAT3 PRKCQ PRKCQ G6PC G6PC LEP LEP IKBKB IKBKB NFKB1 NFKB1 IKBKG IKBKG ACSL4 ACSL4 RXRG RXRG PRKAA2 PRKAA2 NPY NPY PPARA PPARA ACSL5 ACSL5 IRS4 IRS4 AKT3 AKT3 CHUK CHUK MAPK10 MAPK10 AKT1 AKT1 TNFRSF1A TNFRSF1A PRKAG2 PRKAG2 PRKAG1 PRKAG1 MAPK9 MAPK9 MTOR MTOR PRKAA1 PRKAA1 LOC100605369 LOC100605369 IRS1 IRS1 RELA RELA G6PC2 G6PC2 LEPR LEPR PPARGC1A PPARGC1A CAMKK2 CAMKK2 MAPK8 MAPK8 IRS2 IRS2 ADIPOR1 ADIPOR1 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
NFKBIENFKB inhibitor epsilon. (487 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
AGRPAgouti related neuropeptide. (132 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
RXRBRetinoid X receptor beta. (537 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IKBKGNEMO domain-containing protein. (173 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NPYNeuropeptide Y. (97 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (739 aa)
IRS4Insulin receptor substrate 4. (1257 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LOC100605369Uncharacterized protein. (571 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
LEPRLeptin receptor. (1165 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
ADIPOR1Adiponectin receptor 1. (369 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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