50 items (Nomascus leucogenys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	EDN1	Endothelin 1. (211 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (485 aa)
	GNAQ	G protein subunit alpha q. (358 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
	LOC100600502	Guanylate cyclase domain-containing protein. (613 aa)
	PDE3A	Phosphodiesterase. (1141 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (176 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	GUCY1A2	Uncharacterized protein. (385 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1967 aa)
	PRKG2	cGMP-dependent protein kinase. (762 aa)
	GNAI1	G protein subunit alpha i1. (353 aa)
	CLCA2	Chloride channel accessory 2. (943 aa)
	CLCA1	Chloride channel accessory 1. (914 aa)
	CLCA4	Chloride channel accessory 4. (921 aa)
	EDN2	Endothelin 2. (177 aa)
	CALML4	Calmodulin like 4. (196 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (520 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	PDE1B	Phosphodiesterase. (536 aa)
	PDE3B	Phosphodiesterase. (791 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	LOC101176289	Uncharacterized protein. (244 aa)
	ADRB1	Adrenoceptor beta 1. (476 aa)
	ADRB3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (402 aa)
	PPP3R1	Uncharacterized protein. (189 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (408 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	KCNJ2	Potassium voltage-gated channel subfamily J member 2. (427 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (150 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1289 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
	PDE1A	Phosphodiesterase. (544 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	EDN3	Uncharacterized protein. (211 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
	PDE1C	Phosphodiesterase. (766 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
	ACE	Angiotensin-converting enzyme. (1202 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ADRB1	ENSNLEP00000048702	ENSNLEP00000022964	Angiotensin-converting enzyme.	Adrenoceptor beta 1.	0.459
ACE	AGT	ENSNLEP00000048702	ENSNLEP00000002092	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.974
ACE	AGTR1	ENSNLEP00000048702	ENSNLEP00000043125	Angiotensin-converting enzyme.	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.782
ACE	CALML3	ENSNLEP00000048702	ENSNLEP00000027964	Angiotensin-converting enzyme.	Calmodulin like 3; Belongs to the calmodulin family.	0.592
ACE	CALML4	ENSNLEP00000048702	ENSNLEP00000015963	Angiotensin-converting enzyme.	Calmodulin like 4.	0.593
ACE	EDN1	ENSNLEP00000048702	ENSNLEP00000000874	Angiotensin-converting enzyme.	Endothelin 1.	0.587
ADCY5	ADRB1	ENSNLEP00000048270	ENSNLEP00000022964	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adrenoceptor beta 1.	0.518
ADCY5	CALM1	ENSNLEP00000048270	ENSNLEP00000029615	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.915
ADCY5	CALML3	ENSNLEP00000048270	ENSNLEP00000027964	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.935
ADCY5	CALML4	ENSNLEP00000048270	ENSNLEP00000015963	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.933
ADCY5	GNAI1	ENSNLEP00000048270	ENSNLEP00000011705	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.946
ADCY5	GNAI2	ENSNLEP00000048270	ENSNLEP00000008489	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.942
ADCY5	GNAI3	ENSNLEP00000048270	ENSNLEP00000041800	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.942
ADCY5	LOC101176289	ENSNLEP00000048270	ENSNLEP00000022180	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.900
ADCY5	PDE1A	ENSNLEP00000048270	ENSNLEP00000036318	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.724
ADCY5	PDE1B	ENSNLEP00000048270	ENSNLEP00000021396	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.748
ADCY5	PDE1C	ENSNLEP00000048270	ENSNLEP00000046192	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.802
ADCY5	PDE3A	ENSNLEP00000048270	ENSNLEP00000005576	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.809
ADCY5	PDE3B	ENSNLEP00000048270	ENSNLEP00000021492	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.742
ADCY5	PLCB1	ENSNLEP00000048270	ENSNLEP00000017309	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.515

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