STRINGSTRING
GNB1 GNB1 PRKCA PRKCA NOS1 NOS1 MAPK12 MAPK12 EDN1 EDN1 RXFP2 RXFP2 ADCY3 ADCY3 MAP2K7 MAP2K7 MMP2 MMP2 NOS2 NOS2 GNAO1 GNAO1 GNG8 GNG8 GNGT2 GNGT2 NOS3 NOS3 GNG3 GNG3 TGFBR2 TGFBR2 CREB3 CREB3 PIK3CB PIK3CB VEGFB VEGFB PLCB3 PLCB3 KRAS KRAS PIK3CA PIK3CA GNB4 GNB4 PIK3R2 PIK3R2 RXFP1 RXFP1 COL3A1 COL3A1 ATF6B ATF6B MMP9 MMP9 GNAI2 GNAI2 MMP1 MMP1 COL4A1 COL4A1 HRAS HRAS RLN2 RLN2 RLN1 RLN1 MAPK13 MAPK13 COL1A1 COL1A1 VEGFD VEGFD GNAI1 GNAI1 GNG5 GNG5 ADCY2 ADCY2 SHC1 SHC1 SOS2 SOS2 COL4A4 COL4A4 NFKB1 NFKB1 CREB3L2 CREB3L2 TGFB1 TGFB1 PLCB1 PLCB1 PLCB4 PLCB4 ATF4 ATF4 INSL5 INSL5 GNGT1 GNGT1 GNG11 GNG11 COL1A2 COL1A2 EDNRB EDNRB SOS1 SOS1 VEGFC VEGFC ARRB1 ARRB1 ARRB2 ARRB2 LOC101176289 LOC101176289 SMAD2 SMAD2 AKT3 AKT3 RAF1 RAF1 COL4A6 COL4A6 MAPK14 MAPK14 GNG13 GNG13 MAPK10 MAPK10 GNG4 GNG4 MAP2K4 MAP2K4 MAPK1 MAPK1 AKT1 AKT1 LOC100586578 LOC100586578 PRKACB PRKACB GNG2 GNG2 GNB5 GNB5 MAPK9 MAPK9 PIK3R1 PIK3R1 ATF2 ATF2 EGFR EGFR SHC3 SHC3 MAP2K1 MAP2K1 RELA RELA COL4A5 COL4A5 ADCY8 ADCY8 GNG12 GNG12 GNG7 GNG7 NRAS NRAS GRB2 GRB2 TGFBR1 TGFBR1 GNAI3 GNAI3 MMP13 MMP13 PIK3R3 PIK3R3 MAPK8 MAPK8 ADCY1 ADCY1 COL4A3 COL4A3 FOS FOS ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNB1G protein subunit beta 1. (340 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1425 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
EDN1Endothelin 1. (211 aa)
RXFP2Relaxin family peptide receptor 2. (750 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (391 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
GNAO1G protein subunit alpha o1. (353 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3R2Uncharacterized protein. (727 aa)
RXFP1Relaxin family peptide receptor 1. (779 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
GNAI2G protein subunit alpha i2. (355 aa)
MMP1Matrix metallopeptidase 1. (470 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RLN2Relaxin 2. (185 aa)
RLN1Relaxin 1. (185 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GNAI1G protein subunit alpha i1. (353 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
SHC1SHC adaptor protein 1. (542 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ATF4BZIP domain-containing protein. (351 aa)
INSL5Insulin like 5. (135 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (532 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
ARRB1Arrestin beta 1. (418 aa)
ARRB2Arrestin beta 2. (430 aa)
LOC101176289Uncharacterized protein. (244 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
GNG13G protein subunit gamma 13. (67 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
GNB5G protein subunit beta 5. (357 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MMP13Matrix metallopeptidase 13. (474 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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