STRINGSTRING
PRKCA PRKCA CASR CASR NR4A2 NR4A2 GCM2 GCM2 ADCY3 ADCY3 KL KL BRAF BRAF GNAQ GNAQ FGF23 FGF23 MMP15 MMP15 LRP6 LRP6 GCM1 GCM1 ITPR1 ITPR1 CREB3 CREB3 PLCB3 PLCB3 PTHLH PTHLH SOST SOST PRKCG PRKCG MAFB MAFB ATF6B ATF6B RXRB RXRB RHOA RHOA GNAI2 GNAI2 CYP24A1 CYP24A1 MMP17 MMP17 EGR1 EGR1 HBEGF HBEGF MMP25 MMP25 GNAI1 GNAI1 MMP24 MMP24 SLC9A3R1 SLC9A3R1 AKAP13 AKAP13 ADCY2 ADCY2 GATA3 GATA3 FGFR1 FGFR1 SLC34A1 SLC34A1 ARHGEF11 ARHGEF11 CREB3L2 CREB3L2 PLCB1 PLCB1 PLCB4 PLCB4 RXRG RXRG MMP14 MMP14 GNA13 GNA13 ATF4 ATF4 SLC34A2 SLC34A2 ARRB1 ARRB1 CYP27B1 CYP27B1 ARRB2 ARRB2 PLD2 PLD2 PTH PTH SP1 SP1 VDR VDR LOC101176289 LOC101176289 G1S9U7_NOMLE G1S9U7_NOMLE RAF1 RAF1 MEF2A MEF2A TNFSF11 TNFSF11 MAPK1 MAPK1 GNA12 GNA12 PDE4B PDE4B PDE4D PDE4D PRKACB PRKACB BGLAP BGLAP TRPV5 TRPV5 ATF2 ATF2 ITPR2 ITPR2 MMP16 MMP16 PDE4A PDE4A EGFR EGFR MAP2K1 MAP2K1 BCL2 BCL2 MEF2D MEF2D ADCY8 ADCY8 GNAI3 GNAI3 PLD1 PLD1 PRKCB PRKCB MMP13 MMP13 ADCY1 ADCY1 FOS FOS ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
CASRCalcium sensing receptor. (1088 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
GCM2Glial cells missing transcription factor 2. (506 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1131 aa)
KLKlotho. (855 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
GNAQG protein subunit alpha q. (358 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
MMP15Matrix metallopeptidase 15. (669 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2755 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PTHLHParathyroid hormone like hormone. (203 aa)
SOSTSclerostin. (213 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
RXRBRetinoid X receptor beta. (537 aa)
RHOARas homolog family member A. (193 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (513 aa)
MMP17Matrix metallopeptidase 17. (607 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MMP25Matrix metallopeptidase 25. (567 aa)
GNAI1G protein subunit alpha i1. (353 aa)
MMP24Matrix metallopeptidase 24. (563 aa)
SLC9A3R1Uncharacterized protein. (276 aa)
AKAP13A-kinase anchoring protein 13. (2761 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (966 aa)
GATA3GATA binding protein 3. (444 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
SLC34A1Solute carrier family 34 member 1. (601 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1557 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
RXRGRetinoid X receptor gamma. (463 aa)
MMP14Matrix metallopeptidase 14. (586 aa)
GNA13G protein subunit alpha 13. (373 aa)
ATF4BZIP domain-containing protein. (351 aa)
SLC34A2Solute carrier family 34 member 2. (702 aa)
ARRB1Arrestin beta 1. (418 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
ARRB2Arrestin beta 2. (430 aa)
PLD2Phospholipase. (933 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
SP1Sp1 transcription factor. (786 aa)
VDRVitamin D receptor. (427 aa)
LOC101176289Uncharacterized protein. (244 aa)
G1S9U7_NOMLENAC-A/B domain-containing protein. (215 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MEF2AMyocyte enhancer factor 2A. (509 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
GNA12G protein subunit alpha 12. (381 aa)
PDE4BPhosphodiesterase. (736 aa)
PDE4DPhosphodiesterase. (748 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2727 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
PDE4APhosphodiesterase. (869 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MEF2DMADS-box domain-containing protein. (139 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1255 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PLD1Phospholipase. (1074 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MMP13Matrix metallopeptidase 13. (474 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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