STRINGSTRING
PTPN11 PTPN11 PRKAB2 PRKAB2 PRKAB1 PRKAB1 RPS6KB1 RPS6KB1 FOXO1 FOXO1 MLXIP MLXIP AGT AGT GFPT2 GFPT2 RPS6KA6 RPS6KA6 NOS3 NOS3 CREB3 CREB3 PIK3CB PIK3CB GYS2 GYS2 SLC2A2 SLC2A2 G6PC3 G6PC3 NR1H2 NR1H2 PIK3CA PIK3CA PIK3R2 PIK3R2 SLC27A2 SLC27A2 PPP1CA PPP1CA PCK1 PCK1 PRKCD PRKCD PRKAG3 PRKAG3 RPS6KA1 RPS6KA1 LOC100592336 LOC100592336 TRIB3 TRIB3 RPS6KA3 RPS6KA3 PPARGC1B PPARGC1B SLC27A5 SLC27A5 PPP1R3A PPP1R3A STAT3 STAT3 PRKCQ PRKCQ G6PC G6PC PTEN PTEN PYGL PYGL PPP1R3C PPP1R3C IKBKB IKBKB NFKB1 NFKB1 INS-IGF2 INS-IGF2 CREB3L2 CREB3L2 PRKAA2 PRKAA2 PPP1CB PPP1CB PPARA PPARA TBC1D4 TBC1D4 PRKCE PRKCE PPP1R3D PPP1R3D AKT3 AKT3 MAPK10 MAPK10 GSK3B GSK3B AKT1 AKT1 SLC27A1 SLC27A1 TNFRSF1A TNFRSF1A PRKAG2 PRKAG2 PRKAG1 PRKAG1 SREBF1 SREBF1 MAPK9 MAPK9 PIK3R1 PIK3R1 MTOR MTOR PRKAA1 PRKAA1 LOC100605369 LOC100605369 IRS1 IRS1 RELA RELA G6PC2 G6PC2 GFPT1 GFPT1 PPARGC1A PPARGC1A PPP1R3B PPP1R3B PRKCB PRKCB PIK3R3 PIK3R3 MAPK8 MAPK8 IRS2 IRS2 IL6 IL6 OGA OGA TNF TNF SLC27A6 SLC27A6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (276 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
FOXO1Forkhead box O1. (652 aa)
MLXIPMLX interacting protein. (751 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
RPS6KA6Ribosomal protein S6 kinase. (738 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (608 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
RPS6KA3Ribosomal protein S6 kinase. (732 aa)
PPARGC1BPPARG coactivator 1 beta. (1013 aa)
SLC27A5Uncharacterized protein. (95 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1120 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
INS-IGF2INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (203 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
TBC1D4TBC1 domain family member 4. (1298 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
SLC27A1Solute carrier family 27 member 1. (571 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (333 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
LOC100605369Uncharacterized protein. (571 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
PPARGC1APPARG coactivator 1 alpha. (801 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IRS2Insulin receptor substrate 2. (1344 aa)
IL6Uncharacterized protein. (258 aa)
OGAO-GlcNAcase. (926 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SLC27A6Solute carrier family 27 member 6. (612 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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