STRINGSTRING
PRKCA PRKCA MAPK12 MAPK12 EDN1 EDN1 CYBB CYBB FOXO1 FOXO1 MMP2 MMP2 AGT AGT NOS3 NOS3 TGFBR2 TGFBR2 PIK3CB PIK3CB BAX BAX VEGFB VEGFB PLCB3 PLCB3 PLCD1 PLCD1 KRAS KRAS PIK3CA PIK3CA PIK3R2 PIK3R2 COL3A1 COL3A1 AGER AGER PRKCD PRKCD FN1 FN1 COL4A1 COL4A1 SERPINE1 SERPINE1 HRAS HRAS EGR1 EGR1 JAK2 JAK2 MAPK13 MAPK13 COL1A1 COL1A1 VEGFD VEGFD CASP3 CASP3 F3 F3 PIM1 PIM1 STAT3 STAT3 SMAD4 SMAD4 VCAM1 VCAM1 ICAM1 ICAM1 PLCE1 PLCE1 COL4A4 COL4A4 NFKB1 NFKB1 TGFB1 TGFB1 PLCB1 PLCB1 PLCB4 PLCB4 COL1A2 COL1A2 TGFB3 TGFB3 VEGFC VEGFC PRKCE PRKCE CDK4 CDK4 SMAD2 SMAD2 AKT3 AKT3 M3ZBW0_NOMLE M3ZBW0_NOMLE COL4A6 COL4A6 CDKN1B CDKN1B MAPK14 MAPK14 MAPK10 MAPK10 MAPK1 MAPK1 AKT1 AKT1 MAPK9 MAPK9 CCND1 CCND1 PIK3R1 PIK3R1 THBD THBD RELA RELA BCL2 BCL2 COL4A5 COL4A5 SELE SELE NFATC1 NFATC1 NRAS NRAS NOX1 NOX1 CDC42 CDC42 TGFBR1 TGFBR1 SMAD3 SMAD3 AGTR1 AGTR1 PRKCB PRKCB IL1B IL1B PIK3R3 PIK3R3 MAPK8 MAPK8 CXCL8 CXCL8 COL4A3 COL4A3 IL6 IL6 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
MAPK12Mitogen-activated protein kinase. (368 aa)
EDN1Endothelin 1. (211 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
FOXO1Forkhead box O1. (652 aa)
MMP2Matrix metallopeptidase 2. (647 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1128 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BAXUncharacterized protein. (194 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PLCD1Phosphoinositide phospholipase C. (779 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
AGERAdvanced glycosylation end-product specific receptor. (404 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
FN1Fibronectin 1. (2477 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (295 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
CDKN1BUncharacterized protein. (204 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
THBDThrombomodulin. (568 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
SELESelectin E. (612 aa)
NFATC1Nuclear factor of activated T cells 1. (968 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NOX1NADPH oxidase 1. (564 aa)
CDC42Cell division cycle 42. (191 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
IL6Uncharacterized protein. (258 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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