STRINGSTRING
GNB1 GNB1 HDAC10 HDAC10 PPP1R1B PPP1R1B GNAO1 GNAO1 PKIA PKIA FOSB FOSB BRAF BRAF MAOB MAOB HDAC1 HDAC1 GNG8 GNG8 GNGT2 GNGT2 H2BU1 H2BU1 H2BC15 H2BC15 NTRK2 NTRK2 GRIN2B GRIN2B SLC29A1 SLC29A1 H2AZ2 H2AZ2 GNG3 GNG3 CREB3 CREB3 HDAC11 HDAC11 KRAS KRAS HDAC5 HDAC5 GNB4 GNB4 PPP1CA PPP1CA ATF6B ATF6B GNAI2 GNAI2 HRAS HRAS PDYN PDYN GNAI1 GNAI1 HDAC3 HDAC3 GNG5 GNG5 CAMK4 CAMK4 SHC1 SHC1 SOS2 SOS2 CALML4 CALML4 CREB3L2 CREB3L2 LOC100599068 LOC100599068 ADORA2B ADORA2B NPY NPY ATF4 ATF4 PPP1CB PPP1CB GNGT1 GNGT1 GNG11 GNG11 ADORA2A ADORA2A SLC29A3 SLC29A3 SOS1 SOS1 SLC18A2 SLC18A2 GRIN3A GRIN3A BDNF BDNF HDAC8 HDAC8 LOC101176289 LOC101176289 LOC100595867 LOC100595867 H2AC20 H2AC20 LOC100596300 LOC100596300 H2AC1 H2AC1 H2BC1 H2BC1 H2AC11 H2AC11 RAF1 RAF1 HDAC6 HDAC6 LOC100597637 LOC100597637 HIST1H2BK HIST1H2BK GNG13 GNG13 GNG4 GNG4 H2BC18 H2BC18 HIST1H2BO HIST1H2BO MAPK1 MAPK1 LOC100600196 LOC100600196 SLC18A1 SLC18A1 CALML3 CALML3 LOC100586578 LOC100586578 PRKACB PRKACB H3-4 H3-4 DRD2 DRD2 CALM1 CALM1 LOC100593203 LOC100593203 H2BC9 H2BC9 GNG2 GNG2 DDC DDC GNB5 GNB5 CRH CRH HIST2H2BE HIST2H2BE H2AC7 H2AC7 HAT1 HAT1 H2BW1 H2BW1 LOC100593400 LOC100593400 ATF2 ATF2 LOC100595614 LOC100595614 H2BC14 H2BC14 SHC3 SHC3 MAP2K1 MAP2K1 HDAC7 HDAC7 H2BC11 H2BC11 HDAC2 HDAC2 H2AX H2AX DRD1 DRD1 GNG12 GNG12 GNG7 GNG7 HIST1H2AK HIST1H2AK H2BC5 H2BC5 NRAS NRAS GRB2 GRB2 LOC100583243 LOC100583243 H3C13 H3C13 GNAI3 GNAI3 GRIN2A GRIN2A CAMKK2 CAMKK2 LOC100587665 LOC100587665 LOC100591180 LOC100591180 H2AZ1 H2AZ1 H2AC6 H2AC6 H2BC3 H2BC3 MAOA MAOA H2AW H2AW LOC100593825 LOC100593825 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNB1G protein subunit beta 1. (340 aa)
HDAC10Histone deacetylase 10. (670 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
GNAO1G protein subunit alpha o1. (353 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
MAOBAmine oxidase. (520 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1335 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (485 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
HDAC11Histone deacetylase 11. (366 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1154 aa)
GNB4G protein subunit beta 4. (340 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
GNAI2G protein subunit alpha i2. (355 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDYNProdynorphin. (254 aa)
GNAI1G protein subunit alpha i1. (353 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
SHC1SHC adaptor protein 1. (542 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
CALML4Calmodulin like 4. (196 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
LOC100599068Histone H3; Belongs to the histone H3 family. (136 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
NPYNeuropeptide Y. (97 aa)
ATF4BZIP domain-containing protein. (351 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
SLC29A3Solute carrier family 29 member 3. (474 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
SLC18A2Solute carrier family 18 member A2. (514 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1119 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (329 aa)
HDAC8Histone deacetylase 8. (345 aa)
LOC101176289Uncharacterized protein. (244 aa)
LOC100595867Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC100596300Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
H2AC11Histone H2A; Belongs to the histone H2A family. (128 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
HDAC6Uncharacterized protein. (146 aa)
LOC100597637Histone H3; Belongs to the histone H3 family. (136 aa)
HIST1H2BKHistone H2B; Belongs to the histone H2B family. (126 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (116 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (135 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
LOC100600196Histone domain-containing protein; Belongs to the histone H2B family. (125 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC100586578Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (445 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
LOC100593203Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (126 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
DDCDopa decarboxylase. (489 aa)
GNB5G protein subunit beta 5. (357 aa)
CRHCorticotropin releasing hormone. (196 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
H2AC7Histone H2A; Belongs to the histone H2A family. (130 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
H2BW1H2B histone family member W, testis specific; Belongs to the histone H2B family. (176 aa)
LOC100593400Histone H3; Belongs to the histone H3 family. (136 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC100595614Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (142 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HIST1H2AKHistone H2A; Belongs to the histone H2A family. (130 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC100583243Histone H3; Belongs to the histone H3 family. (136 aa)
H3C13Histone H3; Belongs to the histone H3 family. (136 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (591 aa)
LOC100587665Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC100591180Histone domain-containing protein. (136 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
MAOAAmine oxidase. (527 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
LOC100593825Histone H3; Belongs to the histone H3 family. (136 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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