STRINGSTRING
MAPK12 MAPK12 C4BPA C4BPA NOS2 NOS2 CFL2 CFL2 NLRP3 NLRP3 IL12B IL12B C1S C1S MYD88 MYD88 LOC100596445 LOC100596445 RHOA RHOA GNAI2 GNAI2 C4BPB C4BPB CXCL6 CXCL6 CXCL5 CXCL5 C1QA C1QA C1QC C1QC C1QB C1QB MAPK13 MAPK13 CD14 CD14 GNAI1 GNAI1 CASP3 CASP3 IRF8 IRF8 TICAM2 TICAM2 IRF1 IRF1 CALML4 CALML4 TICAM1 TICAM1 NFKB1 NFKB1 NOD1 NOD1 C3 C3 PYCARD PYCARD C5 C5 IL23A IL23A ITGA5 ITGA5 IRAK4 IRAK4 TRAF6 TRAF6 C1R C1R MAPK14 MAPK14 TLR4 TLR4 CFL1 CFL1 SERPING1 SERPING1 MAPK10 MAPK10 MAPK1 MAPK1 CALML3 CALML3 CALM1 CALM1 LY96 LY96 ITGB1 ITGB1 MAPK9 MAPK9 IL10 IL10 LOC100591246 LOC100591246 RELA RELA GNAI3 GNAI3 TIRAP TIRAP CASP1 CASP1 IL1B IL1B MAPK8 MAPK8 CXCL8 CXCL8 IL6 IL6 FOS FOS TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (368 aa)
C4BPAUncharacterized protein. (454 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
NLRP3NLR family pyrin domain containing 3. (1020 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (777 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
LOC100596445Uncharacterized protein. (1744 aa)
RHOARas homolog family member A. (193 aa)
GNAI2G protein subunit alpha i2. (355 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
CXCL6C-X-C motif chemokine. (114 aa)
CXCL5C-X-C motif chemokine. (114 aa)
C1QAComplement C1q A chain. (245 aa)
C1QCComplement C1q C chain. (246 aa)
C1QBComplement C1q B chain. (253 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
GNAI1G protein subunit alpha i1. (353 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
IRF8Interferon regulatory factor 8. (426 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
IRF1Interferon regulatory factor. (324 aa)
CALML4Calmodulin like 4. (196 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (691 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
C3Complement C3. (1424 aa)
PYCARDPYD and CARD domain containing. (195 aa)
C5Complement C5. (1676 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1038 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
C1RCUB domain-containing protein. (147 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (197 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (535 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
LY96Lymphocyte antigen 96. (160 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
IL10Interleukin 10. (178 aa)
LOC100591246Uncharacterized protein. (204 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
GNAI3G protein subunit alpha i3. (354 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IL6Uncharacterized protein. (258 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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