STRINGSTRING
PRKCA PRKCA THOP1 THOP1 GNAQ GNAQ IFNG IFNG IL12B IL12B PLCB3 PLCB3 MYD88 MYD88 PRKCG PRKCG KNG1 KNG1 G1R620_NOMLE G1R620_NOMLE APOA1 APOA1 LOC100583507 LOC100583507 VCAM1 VCAM1 ICAM1 ICAM1 FAS FAS IDO1 IDO1 IDO2 IDO2 LAMA4 LAMA4 PLCB1 PLCB1 PLCB4 PLCB4 FASLG FASLG HBB HBB F2RL1 F2RL1 ENSNLEP00000031690 ENSNLEP00000031690 IL10 IL10 SELE SELE IL18 IL18 PRKCB PRKCB IL1B IL1B IL6 IL6 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
THOP1Thimet oligopeptidase 1. (673 aa)
GNAQG protein subunit alpha q. (358 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
KNG1Kininogen 1. (644 aa)
G1R620_NOMLETIR domain-containing protein. (1031 aa)
APOA1Apolipoprotein A1. (267 aa)
LOC100583507GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
FASFas cell surface death receptor. (335 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (402 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (420 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
HBBHemoglobin subunit beta; Belongs to the globin family. (147 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ENSNLEP00000031690Uncharacterized protein. (59 aa)
IL10Interleukin 10. (178 aa)
SELESelectin E. (612 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL6Uncharacterized protein. (258 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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