32 items (Nomascus leucogenys) - STRING interaction network

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	THBS2	Thrombospondin 2. (1101 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
	COMP	TSP C-terminal domain-containing protein. (194 aa)
	G1R620_NOMLE	TIR domain-containing protein. (1031 aa)
	LOC100583507	GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	ICAM1	Intercellular adhesion molecule 1. (531 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SELP	Selectin P. (830 aa)
	PECAM1	Platelet and endothelial cell adhesion molecule 1. (721 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	HBB	Hemoglobin subunit beta; Belongs to the globin family. (147 aa)
	TLR2	Toll-like receptor. (784 aa)
	ACKR1	Atypical chemokine receptor 1 (Duffy blood group). (338 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
	MET	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
	KLRK1	Killer cell lectin like receptor K1. (216 aa)
	CSF3	Colony stimulating factor 3. (207 aa)
	SDC2	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
	IL10	Interleukin 10. (178 aa)
	SELE	Selectin E. (612 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	CD81	Tetraspanin. (274 aa)
	THBS1	Thrombospondin 1. (1173 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IL6	Uncharacterized protein. (258 aa)
	KLRB1	Killer cell lectin like receptor B1. (225 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)

Your Current Organism:

Nomascus leucogenys

NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR1	COMP	ENSNLEP00000023003	ENSNLEP00000007262	Atypical chemokine receptor 1 (Duffy blood group).	TSP C-terminal domain-containing protein.	0.481
ACKR1	CXCL8	ENSNLEP00000023003	ENSNLEP00000046094	Atypical chemokine receptor 1 (Duffy blood group).	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.646
ACKR1	IL6	ENSNLEP00000023003	ENSNLEP00000047139	Atypical chemokine receptor 1 (Duffy blood group).	Uncharacterized protein.	0.457
CD40LG	CSF3	ENSNLEP00000044715	ENSNLEP00000029072	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Colony stimulating factor 3.	0.566
CD40LG	G1R620_NOMLE	ENSNLEP00000044715	ENSNLEP00000008642	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	TIR domain-containing protein.	0.676
CD40LG	ICAM1	ENSNLEP00000044715	ENSNLEP00000014758	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Intercellular adhesion molecule 1.	0.703
CD40LG	IFNG	ENSNLEP00000044715	ENSNLEP00000004233	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.711
CD40LG	IL10	ENSNLEP00000044715	ENSNLEP00000033936	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin 10.	0.676
CD40LG	IL18	ENSNLEP00000044715	ENSNLEP00000038207	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.621
CD40LG	IL1B	ENSNLEP00000044715	ENSNLEP00000044905	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.698
CD40LG	IL6	ENSNLEP00000044715	ENSNLEP00000047139	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Uncharacterized protein.	0.588
CD40LG	SELE	ENSNLEP00000044715	ENSNLEP00000038032	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Selectin E.	0.486
CD40LG	SELP	ENSNLEP00000044715	ENSNLEP00000018249	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Selectin P.	0.753
CD40LG	TGFB1	ENSNLEP00000044715	ENSNLEP00000016659	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.428
CD40LG	TLR2	ENSNLEP00000044715	ENSNLEP00000022789	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Toll-like receptor.	0.573
CD40LG	TLR4	ENSNLEP00000044715	ENSNLEP00000025448	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.591
CD40LG	TNF	ENSNLEP00000044715	ENSNLEP00000047690	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.802
CD40LG	VCAM1	ENSNLEP00000044715	ENSNLEP00000014455	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Vascular cell adhesion molecule 1.	0.497
CD81	ICAM1	ENSNLEP00000040088	ENSNLEP00000014758	Tetraspanin.	Intercellular adhesion molecule 1.	0.665
CD81	KLRK1	ENSNLEP00000040088	ENSNLEP00000025971	Tetraspanin.	Killer cell lectin like receptor K1.	0.400

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