STRINGSTRING
MAPK12 MAPK12 LAMB3 LAMB3 NOS2 NOS2 GNAO1 GNAO1 MAP2K6 MAP2K6 IFNG IFNG IL10RB IL10RB IFNGR2 IFNGR2 IL12B IL12B MYD88 MYD88 HLA-DRA HLA-DRA HLA-DQA2 HLA-DQA2 LAMA3 LAMA3 LOC100606816 LOC100606816 HLA-DPB1 HLA-DPB1 LAMA1 LAMA1 GNAI2 GNAI2 BIRC3 BIRC3 IL10RA IL10RA CASP9 CASP9 LAMB4 LAMB4 LAMB1 LAMB1 PIK3CG PIK3CG JAK2 JAK2 MAPK13 MAPK13 LOC100592336 LOC100592336 GNAI1 GNAI1 BCL2L1 BCL2L1 BIRC7 BIRC7 PIK3R5 PIK3R5 CASP3 CASP3 STAT3 STAT3 TYK2 TYK2 LAMC3 LAMC3 IKBKB IKBKB LAMA4 LAMA4 NFKB1 NFKB1 MAP3K7 MAP3K7 TGFB1 TGFB1 IKBKG IKBKG CYCS CYCS XIAP XIAP JAK1 JAK1 TAB1 TAB1 TAB2 TAB2 TGFB3 TGFB3 IRAK4 IRAK4 TRAF6 TRAF6 LAMC1 LAMC1 SOCS1 SOCS1 TLR2 TLR2 HSPA6 HSPA6 AKT3 AKT3 MAPK14 MAPK14 TLR4 TLR4 CHUK CHUK MAPK10 MAPK10 MAPK1 MAPK1 AKT1 AKT1 PPIF PPIF HLA-DPA1 HLA-DPA1 TNFRSF1A TNFRSF1A LOC100600457 LOC100600457 LAMC2 LAMC2 HLA-DQA1 HLA-DQA1 LY96 LY96 ITGB1 ITGB1 MAPK9 MAPK9 LOC100598207 LOC100598207 IL10 IL10 LOC101179576 LOC101179576 LAMA2 LAMA2 RELA RELA BCL2 BCL2 HLA-DMA HLA-DMA ITGA6 ITGA6 IFNGR1 IFNGR1 BIRC2 BIRC2 BAD BAD ENSNLEP00000038814 ENSNLEP00000038814 HLA-DOB HLA-DOB CASP8 CASP8 GNAI3 GNAI3 HLA-DQB1 HLA-DQB1 CD40LG CD40LG HSPA8 HSPA8 MAPK8 MAPK8 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK12Mitogen-activated protein kinase. (368 aa)
LAMB3Laminin subunit beta 3. (1137 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
GNAO1G protein subunit alpha o1. (353 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
IFNGR2Interferon gamma receptor 2. (314 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
HLA-DQA2Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family. (255 aa)
LAMA3Laminin subunit alpha 3. (3316 aa)
LOC100606816Ig-like domain-containing protein. (263 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
GNAI2G protein subunit alpha i2. (355 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
IL10RAInterleukin 10 receptor subunit alpha. (557 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
LAMB4Laminin subunit beta 4. (1753 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
GNAI1G protein subunit alpha i1. (353 aa)
BCL2L1BCL2 like 1. (217 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (889 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
LAMC3Laminin subunit gamma 3. (1550 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IKBKGNEMO domain-containing protein. (173 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
SOCS1Suppressor of cytokine signaling 1. (208 aa)
TLR2Toll-like receptor. (784 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (260 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
LOC100600457Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LAMC2Laminin subunit gamma 2. (1178 aa)
HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family. (255 aa)
LY96Lymphocyte antigen 96. (160 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
LOC100598207Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IL10Interleukin 10. (178 aa)
LOC101179576Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
LAMA2Laminin subunit alpha 2. (3062 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (292 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
IFNGR1Interferon gamma receptor 1. (489 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
BADUncharacterized protein. (82 aa)
ENSNLEP00000038814Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (273 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
GNAI3G protein subunit alpha i3. (354 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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