STRINGSTRING
PRKCA PRKCA ARG2 ARG2 LAMB3 LAMB3 NOS2 NOS2 GNA14 GNA14 GNAQ GNAQ RAB5A RAB5A IFNG IFNG IL12B IL12B PIK3CB PIK3CB PLCB3 PLCB3 PIK3CA PIK3CA PIK3R2 PIK3R2 PRKCG PRKCG COL3A1 COL3A1 LAMA3 LAMA3 LAMA1 LAMA1 FN1 FN1 COL4A1 COL4A1 CXCL3 CXCL3 CXCL2 CXCL2 LAMB4 LAMB4 LAMB1 LAMB1 C8G C8G G1RC58_NOMLE G1RC58_NOMLE SERPINB10 SERPINB10 COL1A1 COL1A1 CD14 CD14 CASP3 CASP3 RAB5C RAB5C LAMC3 LAMC3 CSF2 CSF2 CD1D CD1D CD1A CD1A CD1C CD1C LAMA4 LAMA4 CD1B CD1B CD1E CD1E COL4A4 COL4A4 NFKB1 NFKB1 TGFB1 TGFB1 PLCB1 PLCB1 ARG1 ARG1 PLCB4 PLCB4 IL1R2 IL1R2 C8A C8A COL1A2 COL1A2 C9 C9 TGFB3 TGFB3 LAMC1 LAMC1 LOC101176289 LOC101176289 TLR2 TLR2 IL1R1 IL1R1 COL4A6 COL4A6 RAB7A RAB7A TLR4 TLR4 HSPB1 HSPB1 PRKACB PRKACB CTSG CTSG C8B C8B ACTN4 ACTN4 LAMC2 LAMC2 PIK3R1 PIK3R1 IL10 IL10 LAMA2 LAMA2 RELA RELA COL4A5 COL4A5 SERPINB13 SERPINB13 GNAL GNAL PRKCB PRKCB IL1B IL1B PIK3R3 PIK3R3 SERPINB9 SERPINB9 CXCL8 CXCL8 RAB5B RAB5B ACTN1 ACTN1 ADCY1 ADCY1 PRDX1 PRDX1 COL4A3 COL4A3 IL6 IL6 MUC2 MUC2 TNF TNF SERPINB6 SERPINB6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
ARG2Arginase. (354 aa)
LAMB3Laminin subunit beta 3. (1137 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAQG protein subunit alpha q. (358 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
LAMA3Laminin subunit alpha 3. (3316 aa)
LAMA1Laminin subunit alpha 1. (3033 aa)
FN1Fibronectin 1. (2477 aa)
COL4A1Collagen type IV alpha 1 chain. (1629 aa)
CXCL3C-X-C motif chemokine. (107 aa)
CXCL2C-X-C motif chemokine. (106 aa)
LAMB4Laminin subunit beta 4. (1753 aa)
LAMB1Laminin subunit beta 1. (1810 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
G1RC58_NOMLESERPIN domain-containing protein; Belongs to the serpin family. (321 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (397 aa)
COL1A1Collagen type I alpha 1 chain. (1386 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
RAB5CRAB5C, member RAS oncogene family. (249 aa)
LAMC3Laminin subunit gamma 3. (1550 aa)
CSF2Colony stimulating factor 2. (144 aa)
CD1DCD1d molecule. (334 aa)
CD1ACD1a molecule. (327 aa)
CD1CCD1c molecule. (333 aa)
LAMA4Laminin subunit alpha 4. (1823 aa)
CD1BCD1b molecule. (333 aa)
CD1ECD1e molecule. (388 aa)
COL4A4Collagen type IV alpha 4 chain. (1678 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ARG1Arginase. (322 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
C8AComplement C8 alpha chain. (584 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
C9Complement C9. (561 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
LOC101176289Uncharacterized protein. (244 aa)
TLR2Toll-like receptor. (784 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
HSPB1Uncharacterized protein. (37 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (255 aa)
C8BComplement C8 beta chain. (544 aa)
ACTN4Actinin alpha 4. (931 aa)
LAMC2Laminin subunit gamma 2. (1178 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
IL10Interleukin 10. (178 aa)
LAMA2Laminin subunit alpha 2. (3062 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (400 aa)
GNALG protein subunit alpha L. (452 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (375 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
RAB5BUncharacterized protein. (228 aa)
ACTN1Actinin alpha 1. (921 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
PRDX1Peroxiredoxin 1. (199 aa)
COL4A3Collagen type IV alpha 3 chain. (1600 aa)
IL6Uncharacterized protein. (258 aa)
MUC2Uncharacterized protein. (1539 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SERPINB6Serpin family B member 6; Belongs to the serpin family. (403 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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