STRINGSTRING
OAS3 OAS3 OAS2 OAS2 MSN MSN EIF2S1 EIF2S1 EIF2AK1 EIF2AK1 IL2RG IL2RG EIF2AK3 EIF2AK3 CCNE2 CCNE2 IL12B IL12B TRADD TRADD PIK3CB PIK3CB BAX BAX MYD88 MYD88 PIK3CA PIK3CA PIK3R2 PIK3R2 APAF1 APAF1 CD28 CD28 G1R620_NOMLE G1R620_NOMLE CD3G CD3G CCNE1 CCNE1 CASP9 CASP9 IRF7 IRF7 MX2 MX2 TLR7 TLR7 IL2 IL2 CSNK2A1 CSNK2A1 BCL2L1 BCL2L1 FADD FADD CASP3 CASP3 ADAR ADAR STAT3 STAT3 IL2RA IL2RA TYK2 TYK2 FAS FAS IKBKB IKBKB NFKB1 NFKB1 MAP3K7 MAP3K7 IKBKG IKBKG CYCS CYCS TNFAIP3 TNFAIP3 JAK1 JAK1 FASLG FASLG IRF9 IRF9 TAB2 TAB2 TRAF3 TRAF3 TBK1 TBK1 CDK4 CDK4 IRAK4 IRAK4 TRAF6 TRAF6 RAB9B RAB9B TLR2 TLR2 G1SBE5_NOMLE G1SBE5_NOMLE IFNB1 IFNB1 HSPA6 HSPA6 IFIH1 IFIH1 AKT3 AKT3 M3ZBW0_NOMLE M3ZBW0_NOMLE CDK6 CDK6 CDKN1B CDKN1B TLR4 TLR4 CHUK CHUK RAB9A RAB9A STAT2 STAT2 MAPK10 MAPK10 GSK3B GSK3B LOC100595932 LOC100595932 IFNA6 IFNA6 AKT1 AKT1 IFNA8 IFNA8 INSL3 INSL3 LOC100600457 LOC100600457 RCHY1 RCHY1 MX1 MX1 EIF3H EIF3H MAPK9 MAPK9 CCND1 CCND1 PIK3R1 PIK3R1 LOC100598207 LOC100598207 SLAMF1 SLAMF1 LOC101179576 LOC101179576 BAK1 BAK1 RELA RELA EIF2AK4 EIF2AK4 BCL2 BCL2 BID BID OAS1 OAS1 BAD BAD ENSNLEP00000038814 ENSNLEP00000038814 CASP8 CASP8 IFNAR1 IFNAR1 CCND3 CCND3 CD3E CD3E IFNA5 IFNA5 IL1B IL1B HSPA8 HSPA8 PIK3R3 PIK3R3 MAPK8 MAPK8 IL6 IL6 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OAS32'-5'-oligoadenylate synthetase 3. (1072 aa)
OAS22'-5'-oligoadenylate synthetase 2. (719 aa)
MSNMoesin. (566 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (614 aa)
IL2RGFibronectin type-III domain-containing protein. (369 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1120 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BAXUncharacterized protein. (194 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
CD28CD28 molecule. (220 aa)
G1R620_NOMLETIR domain-containing protein. (1031 aa)
CD3GCD3g molecule. (182 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (402 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
IRF7Interferon regulatory factor 7. (524 aa)
MX2MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (645 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
BCL2L1BCL2 like 1. (217 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
ADARAdenosine deaminase RNA specific. (1180 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
FASFas cell surface death receptor. (335 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IKBKGNEMO domain-containing protein. (173 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
IRF9Interferon regulatory factor 9. (392 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
TBK1TANK binding kinase 1. (729 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
TLR2Toll-like receptor. (784 aa)
G1SBE5_NOMLEUncharacterized protein. (198 aa)
IFNB1Interferon beta 1. (187 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
IFIH1Interferon induced with helicase C domain 1. (976 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDKN1BUncharacterized protein. (204 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
STAT2Signal transducer and activator of transcription. (852 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
LOC100595932Uncharacterized protein. (198 aa)
IFNA6Interferon alpha 6. (190 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
IFNA8Interferon alpha 8. (189 aa)
INSL3Insulin like 3. (157 aa)
LOC100600457Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
MX1Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (671 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (366 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
LOC100598207Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (331 aa)
LOC101179576Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1642 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (214 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
BADUncharacterized protein. (82 aa)
ENSNLEP00000038814Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (557 aa)
CCND3Uncharacterized protein; Belongs to the cyclin family. (242 aa)
CD3ECD3e molecule. (198 aa)
IFNA5Interferon alpha 5. (189 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL6Uncharacterized protein. (258 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (26%) [HD]