STRINGSTRING
TBP TBP SYK SYK HDAC10 HDAC10 MAPKAPK2 MAPKAPK2 RBL2 RBL2 LYN LYN ATP6V0D2 ATP6V0D2 IL6ST IL6ST DDB1 DDB1 TRAF5 TRAF5 HDAC1 HDAC1 H2BU1 H2BU1 H2BC15 H2BC15 RB1 RB1 CCNE2 CCNE2 SRF SRF CREB3 CREB3 TRADD TRADD PIK3CB PIK3CB CHD4 CHD4 LOC100582721 LOC100582721 BAX BAX YWHAH YWHAH HDAC11 HDAC11 LOC100592911 LOC100592911 GTF2E1 GTF2E1 MRPS18B MRPS18B KRAS KRAS HDAC5 HDAC5 GTF2H4 GTF2H4 RANBP1 RANBP1 PIK3CA PIK3CA PIK3R2 PIK3R2 LOC100579523 LOC100579523 RBL1 RBL1 ATF6B ATF6B YWHAB YWHAB RHOA RHOA CCNE1 CCNE1 UBR4 UBR4 HRAS HRAS IRF7 IRF7 TRAF2 TRAF2 CCNA2 CCNA2 HDAC3 HDAC3 CREBBP CREBBP DNAJA3 DNAJA3 USP7 USP7 GTF2B GTF2B CASP3 CASP3 KAT2A KAT2A STAT3 STAT3 GTF2E2 GTF2E2 SND1 SND1 TBPL2 TBPL2 POLB POLB VDAC3 VDAC3 NFKB1 NFKB1 CDC20 CDC20 YWHAQ YWHAQ CREB3L2 CREB3L2 SP100 SP100 IKBKG IKBKG TBPL1 TBPL1 NFKB2 NFKB2 JAK1 JAK1 ATF4 ATF4 IRF9 IRF9 CCNA1 CCNA1 EGR3 EGR3 C3 C3 SKP2 SKP2 TRAF3 TRAF3 VAC14 VAC14 SCIN SCIN RBPJ RBPJ PSMC1 PSMC1 TRAF1 TRAF1 CDK4 CDK4 GTF2H1 GTF2H1 HDAC8 HDAC8 LOC100596300 LOC100596300 CCR4 CCR4 H2BC1 H2BC1 RASA2 RASA2 M3ZBW0_NOMLE M3ZBW0_NOMLE CDK6 CDK6 HDAC6 HDAC6 CDKN1B CDKN1B KAT2B KAT2B ENSNLEP00000025590 ENSNLEP00000025590 HIST1H2BK HIST1H2BK H2BC18 H2BC18 HIST1H2BO HIST1H2BO MAPK1 MAPK1 LOC100600196 LOC100600196 CDK1 CDK1 DDX3X DDX3X YWHAZ YWHAZ DLG1 DLG1 PRKACB PRKACB SNW1 SNW1 INSL3 INSL3 ENSNLEP00000029648 ENSNLEP00000029648 LOC100593203 LOC100593203 H2BC9 H2BC9 ACTN4 ACTN4 HIST2H2BE HIST2H2BE CCND1 CCND1 PIK3R1 PIK3R1 H2BW1 H2BW1 GTF2A1 GTF2A1 ATF2 ATF2 BAK1 BAK1 H2BC14 H2BC14 RELA RELA HDAC7 HDAC7 H2BC11 H2BC11 CDKN2A CDKN2A BAD BAD HDAC2 HDAC2 H2BC5 H2BC5 CHEK1 CHEK1 NRAS NRAS CASP8 CASP8 GRB2 GRB2 CDC42 CDC42 CCND3 CCND3 LOC100587665 LOC100587665 GTF2H3 GTF2H3 GTF2A2 GTF2A2 YWHAE YWHAE H2BC3 H2BC3 EGR2 EGR2 PIK3R3 PIK3R3 UBE3A UBE3A ACTN1 ACTN1 CDKN2B CDKN2B PXN PXN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBPTATA-box binding protein. (328 aa)
SYKTyrosine-protein kinase. (532 aa)
HDAC10Histone deacetylase 10. (670 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (370 aa)
RBL2RB transcriptional corepressor like 2. (1138 aa)
LYNTyrosine-protein kinase. (512 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
DDB1Damage specific DNA binding protein 1. (1139 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
RB1RB transcriptional corepressor 1. (919 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
SRFSerum response factor. (508 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
CHD4Uncharacterized protein. (1987 aa)
LOC100582721General transcription factor IIH subunit. (395 aa)
BAXUncharacterized protein. (194 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
HDAC11Histone deacetylase 11. (366 aa)
LOC100592911Ig-like domain-containing protein; Belongs to the MHC class I family. (295 aa)
GTF2E1General transcription factor IIE subunit 1. (439 aa)
MRPS18BMitochondrial ribosomal protein S18B. (258 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1154 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
RANBP1RAN binding protein 1. (278 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
LOC100579523Major histocompatibility complex, class I, B; Belongs to the MHC class I family. (365 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
ATF6BActivating transcription factor 6 beta. (718 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
RHOARas homolog family member A. (193 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (402 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5170 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
IRF7Interferon regulatory factor 7. (524 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CREBBPCREB binding protein. (2442 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (432 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
GTF2BGeneral transcription factor IIB. (316 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
KAT2AUncharacterized protein. (476 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
TBPL2TATA-box binding protein like 2. (375 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CDC20Cell division cycle 20. (498 aa)
YWHAQ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (253 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
SP100SP100 nuclear antigen. (885 aa)
IKBKGNEMO domain-containing protein. (173 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
ATF4BZIP domain-containing protein. (351 aa)
IRF9Interferon regulatory factor 9. (392 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
EGR3Early growth response 3. (387 aa)
C3Complement C3. (1424 aa)
SKP2S-phase kinase associated protein 2. (425 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
SCINScinderin. (715 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (527 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
TRAF1TNF receptor-associated factor. (416 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
HDAC8Histone deacetylase 8. (345 aa)
LOC100596300Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
RASA2RAS p21 protein activator 2. (849 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HDAC6Uncharacterized protein. (146 aa)
CDKN1BUncharacterized protein. (204 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (799 aa)
ENSNLEP00000025590Ig-like domain-containing protein; Belongs to the MHC class I family. (340 aa)
HIST1H2BKHistone H2B; Belongs to the histone H2B family. (126 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (135 aa)
HIST1H2BOHistone H2B; Belongs to the histone H2B family. (126 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
LOC100600196Histone domain-containing protein; Belongs to the histone H2B family. (125 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (704 aa)
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (916 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SNW1SNW domain containing 1. (571 aa)
INSL3Insulin like 3. (157 aa)
ENSNLEP00000029648Ig-like domain-containing protein; Belongs to the MHC class I family. (411 aa)
LOC100593203Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (126 aa)
ACTN4Actinin alpha 4. (931 aa)
HIST2H2BEHistone H2B; Belongs to the histone H2B family. (126 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
H2BW1H2B histone family member W, testis specific; Belongs to the histone H2B family. (176 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
H2BC14Histone H2B; Belongs to the histone H2B family. (126 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1004 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
BADUncharacterized protein. (82 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (533 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
CHEK1Checkpoint kinase 1. (492 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Cell division cycle 42. (191 aa)
CCND3Uncharacterized protein; Belongs to the cyclin family. (242 aa)
LOC100587665Histone H2B; Belongs to the histone H2B family. (126 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
EGR2Early growth response 2. (476 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (881 aa)
ACTN1Actinin alpha 1. (921 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PXNUncharacterized protein. (1078 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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