STRINGSTRING
BIRC5 BIRC5 GADD45G GADD45G RPS6KB1 RPS6KB1 RALB RALB TCF7L1 TCF7L1 BRAF BRAF BCL2L11 BCL2L11 RALA RALA TGFBR2 TGFBR2 PIK3CB PIK3CB BAX BAX MLH1 MLH1 KRAS KRAS MYC MYC PIK3CA PIK3CA CTNNB1 CTNNB1 PIK3R2 PIK3R2 RHOA RHOA CASP9 CASP9 EREG EREG HRAS HRAS MSH6 MSH6 GADD45A GADD45A TGFA TGFA CASP3 CASP3 APC APC SMAD4 SMAD4 SOS2 SOS2 MSH3 MSH3 RALGDS RALGDS TGFB1 TGFB1 AXIN2 AXIN2 CYCS CYCS TCF7L2 TCF7L2 SOS1 SOS1 EGF EGF TGFB3 TGFB3 SMAD2 SMAD2 MSH2 MSH2 AKT3 AKT3 RAF1 RAF1 MAPK10 MAPK10 GSK3B GSK3B MAPK1 MAPK1 AKT1 AKT1 LOC100600457 LOC100600457 MAPK9 MAPK9 CCND1 CCND1 PIK3R1 PIK3R1 LOC100598207 LOC100598207 MTOR MTOR LEF1 LEF1 LOC101179576 LOC101179576 BAK1 BAK1 EGFR EGFR MAP2K1 MAP2K1 BCL2 BCL2 BAD BAD ENSNLEP00000038814 ENSNLEP00000038814 AREG AREG NRAS NRAS GRB2 GRB2 TGFBR1 TGFBR1 SMAD3 SMAD3 RAC2 RAC2 POLK POLK PIK3R3 PIK3R3 MAPK8 MAPK8 TCF7 TCF7 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BIRC5Uncharacterized protein. (91 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
RALBRAS like proto-oncogene B. (212 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
RALARAS like proto-oncogene A. (206 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BAXUncharacterized protein. (194 aa)
MLH1MutL homolog 1. (756 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R2Uncharacterized protein. (727 aa)
RHOARas homolog family member A. (193 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
EREGEpiregulin. (169 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1273 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
TGFATransforming growth factor alpha. (166 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1099 aa)
RALGDSUncharacterized protein. (916 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
AXIN2DIX domain-containing protein. (294 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
LOC100600457Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
LOC100598207Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
LOC101179576Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
BADUncharacterized protein. (82 aa)
ENSNLEP00000038814Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (107 aa)
AREGEGF-like domain-containing protein. (274 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RAC2Rac family small GTPase 2. (192 aa)
POLKDNA polymerase kappa. (896 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TCF7HMG box domain-containing protein. (486 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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