STRINGSTRING
PTPN11 PTPN11 CRKL CRKL CRK CRK PAK2 PAK2 BRAF BRAF PAK6 PAK6 EGLN3 EGLN3 RAP1A RAP1A PIK3CB PIK3CB KRAS KRAS GAB1 GAB1 PIK3CA PIK3CA PIK3R2 PIK3R2 ETS1 ETS1 TFE3 TFE3 HRAS HRAS CREBBP CREBBP ARNT ARNT TGFA TGFA SOS2 SOS2 PRCC PRCC TGFB1 TGFB1 EGLN2 EGLN2 PAK5 PAK5 PAK4 PAK4 PDGFB PDGFB SOS1 SOS1 TGFB3 TGFB3 EPAS1 EPAS1 LOC100604447 LOC100604447 AKT3 AKT3 HGF HGF RAF1 RAF1 MET MET MAPK1 MAPK1 FH FH AKT1 AKT1 ELOC ELOC PIK3R1 PIK3R1 ELOB-2 ELOB-2 LOC100605369 LOC100605369 MAP2K1 MAP2K1 RBX1 RBX1 ARNT2 ARNT2 EGLN1 EGLN1 BAD BAD PAK1 PAK1 CUL2 CUL2 LOC100581166 LOC100581166 NRAS NRAS GRB2 GRB2 CDC42 CDC42 PIK3R3 PIK3R3 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CRKUncharacterized protein. (252 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CREBBPCREB binding protein. (2442 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
TGFATransforming growth factor alpha. (166 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (407 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
LOC100604447Ubiquitin-like domain-containing protein. (118 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
FHFumarate hydratase. (510 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (96 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
ELOB-2Ubiquitin-like domain-containing protein. (142 aa)
LOC100605369Uncharacterized protein. (571 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RBX1Ring-box 1. (108 aa)
ARNT2Uncharacterized protein. (699 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (416 aa)
BADUncharacterized protein. (82 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
CUL2Uncharacterized protein. (90 aa)
LOC100581166Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42Cell division cycle 42. (191 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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