STRINGSTRING
GADD45G GADD45G RPS6KB1 RPS6KB1 RALB RALB BRCA2 BRCA2 BRAF BRAF ARHGEF6 ARHGEF6 RALA RALA RB1 RB1 TGFBR2 TGFBR2 PIK3CB PIK3CB BAX BAX KRAS KRAS PIK3CA PIK3CA PIK3R2 PIK3R2 RALBP1 RALBP1 CASP9 CASP9 E2F2 E2F2 GADD45A GADD45A BCL2L1 BCL2L1 E2F1 E2F1 TGFA TGFA STAT3 STAT3 SMAD4 SMAD4 IKBKB IKBKB RALGDS RALGDS NFKB1 NFKB1 TGFB1 TGFB1 IKBKG IKBKG JAK1 JAK1 EGF EGF TGFB3 TGFB3 CDK4 CDK4 PLD2 PLD2 SMAD2 SMAD2 AKT3 AKT3 CDK6 CDK6 RAF1 RAF1 CHUK CHUK MAPK10 MAPK10 MAPK1 MAPK1 AKT1 AKT1 MAPK9 MAPK9 CCND1 CCND1 PIK3R1 PIK3R1 MTOR MTOR BAK1 BAK1 EGFR EGFR MAP2K1 MAP2K1 RELA RELA RAD51 RAD51 CDKN2A CDKN2A BAD BAD CDC42 CDC42 TGFBR1 TGFBR1 SMAD3 SMAD3 E2F3 E2F3 RAC2 RAC2 PLD1 PLD1 POLK POLK PIK3R3 PIK3R3 MAPK8 MAPK8 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
RALBRAS like proto-oncogene B. (212 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
RALARAS like proto-oncogene A. (206 aa)
RB1RB transcriptional corepressor 1. (919 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BAXUncharacterized protein. (194 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
RALBP1RalA binding protein 1. (655 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
E2F2E2F transcription factor 2. (437 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
BCL2L1BCL2 like 1. (217 aa)
E2F1E2F transcription factor 1. (391 aa)
TGFATransforming growth factor alpha. (166 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
RALGDSUncharacterized protein. (916 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IKBKGNEMO domain-containing protein. (173 aa)
JAK1Tyrosine-protein kinase. (1149 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PLD2Phospholipase. (933 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
BADUncharacterized protein. (82 aa)
CDC42Cell division cycle 42. (191 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (498 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
E2F3E2F transcription factor 3. (397 aa)
RAC2Rac family small GTPase 2. (192 aa)
PLD1Phospholipase. (1074 aa)
POLKDNA polymerase kappa. (896 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.