STRINGSTRING
GADD45G GADD45G TCF7L1 TCF7L1 BRAF BRAF PIK3CB PIK3CB BAX BAX MLH1 MLH1 KRAS KRAS CDH1 CDH1 MYC MYC PIK3CA PIK3CA CTNNB1 CTNNB1 PIK3R2 PIK3R2 CASP9 CASP9 HRAS HRAS GADD45A GADD45A LOC100592336 LOC100592336 APC APC CTNNA3 CTNNA3 SOS2 SOS2 PTEN PTEN AXIN2 AXIN2 TCF7L2 TCF7L2 SOS1 SOS1 EGF EGF FOXO3 FOXO3 AKT3 AKT3 RAF1 RAF1 GSK3B GSK3B MAPK1 MAPK1 AKT1 AKT1 CCND1 CCND1 PIK3R1 PIK3R1 CTNNA1 CTNNA1 LEF1 LEF1 BAK1 BAK1 EGFR EGFR MAP2K1 MAP2K1 BAD BAD NRAS NRAS GRB2 GRB2 ILK ILK POLK POLK PIK3R3 PIK3R3 TCF7 TCF7 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
BAXUncharacterized protein. (194 aa)
MLH1MutL homolog 1. (756 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R2Uncharacterized protein. (727 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (426 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LOC100592336PH_3 domain-containing protein. (247 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
CTNNA3Catenin alpha 3. (895 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
AXIN2DIX domain-containing protein. (294 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
FOXO3Forkhead box O3. (672 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
CTNNA1Catenin alpha 1. (895 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BADUncharacterized protein. (82 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ILKIntegrin linked kinase. (458 aa)
POLKDNA polymerase kappa. (896 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
TCF7HMG box domain-containing protein. (486 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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