STRINGSTRING
MMP2 MMP2 BRAF BRAF DAPK3 DAPK3 RB1 RB1 KRAS KRAS DAPK1 DAPK1 CDH1 CDH1 MYC MYC MMP9 MMP9 MMP1 MMP1 HRAS HRAS E2F2 E2F2 HBEGF HBEGF E2F1 E2F1 EGF EGF CDK4 CDK4 RAF1 RAF1 DAPK2 DAPK2 MAPK1 MAPK1 RPS6KA5 RPS6KA5 CCND1 CCND1 EGFR EGFR MAP2K1 MAP2K1 CDKN2A CDKN2A NRAS NRAS E2F3 E2F3 THBS1 THBS1 CXCL8 CXCL8 RASSF1 RASSF1 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP2Matrix metallopeptidase 2. (647 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
DAPK3Death associated protein kinase 3. (407 aa)
RB1RB transcriptional corepressor 1. (919 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (883 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
MMP9Matrix metallopeptidase 9. (692 aa)
MMP1Matrix metallopeptidase 1. (470 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (437 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
E2F1E2F transcription factor 1. (391 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
RPS6KA5Ribosomal protein S6 kinase. (797 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (159 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
E2F3E2F transcription factor 3. (397 aa)
THBS1Thrombospondin 1. (1173 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
RASSF1Ras association domain family member 1. (304 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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