STRINGSTRING
FLT3 FLT3 RPS6KB1 RPS6KB1 TCF7L1 TCF7L1 RARA RARA BRAF BRAF PIK3CB PIK3CB KRAS KRAS MYC MYC PIK3CA PIK3CA PIK3R2 PIK3R2 ZBTB16 ZBTB16 PIM2 PIM2 MPO MPO HRAS HRAS KIT KIT CD14 CD14 CCNA2 CCNA2 CSF1R CSF1R JUP JUP PIM1 PIM1 PER2 PER2 STAT3 STAT3 SOS2 SOS2 IL3 IL3 CSF2 CSF2 IKBKB IKBKB NFKB1 NFKB1 IKBKG IKBKG SPI1 SPI1 CEBPE CEBPE CCNA1 CCNA1 TCF7L2 TCF7L2 SOS1 SOS1 AKT3 AKT3 PPARD PPARD M3ZBW0_NOMLE M3ZBW0_NOMLE RAF1 RAF1 CHUK CHUK MAPK1 MAPK1 AKT1 AKT1 CCND1 CCND1 PIK3R1 PIK3R1 MTOR MTOR LEF1 LEF1 MAP2K1 MAP2K1 RELA RELA BAD BAD NRAS NRAS GRB2 GRB2 RUNX1 RUNX1 DUSP6 DUSP6 BCL2A1 BCL2A1 PIK3R3 PIK3R3 PML PML TCF7 TCF7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
RARARetinoic acid receptor alpha. (458 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
MPOMyeloperoxidase. (745 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (431 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
JUPJunction plakoglobin. (730 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
PER2Period circadian regulator 2. (1277 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (152 aa)
CSF2Colony stimulating factor 2. (144 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (745 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
IKBKGNEMO domain-containing protein. (173 aa)
SPI1Spi-1 proto-oncogene. (271 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
M3ZBW0_NOMLESH2 domain-containing protein. (230 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (743 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BADUncharacterized protein. (82 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (485 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
BCL2A1Uncharacterized protein. (205 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
PMLUncharacterized protein. (873 aa)
TCF7HMG box domain-containing protein. (486 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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