STRINGSTRING
GADD45G GADD45G RPS6KB1 RPS6KB1 FGF22 FGF22 BRCA2 BRCA2 FGF16 FGF16 TCF7L1 TCF7L1 BRAF BRAF FLT4 FLT4 WNT5B WNT5B FGF23 FGF23 FGF6 FGF6 RB1 RB1 LRP6 LRP6 FZD6 FZD6 WNT2B WNT2B PIK3CB PIK3CB FGF21 FGF21 BAX BAX WNT3 WNT3 WNT9B WNT9B KRAS KRAS NOTCH2 NOTCH2 MYC MYC PIK3CA PIK3CA CTNNB1 CTNNB1 PIK3R2 PIK3R2 FGF7 FGF7 NCOA3 NCOA3 PGR PGR WNT5A WNT5A WNT4 WNT4 HRAS HRAS KIT KIT FGF5 FGF5 E2F2 E2F2 WNT6 WNT6 WNT10A WNT10A GADD45A GADD45A FGF1 FGF1 E2F1 E2F1 FGF19 FGF19 SHC1 SHC1 APC APC WNT2 WNT2 WNT16 WNT16 HEYL HEYL SOS2 SOS2 PTEN PTEN FGFR1 FGFR1 FGF9 FGF9 WNT7B WNT7B HEY2 HEY2 ESR2 ESR2 WNT8B WNT8B AXIN2 AXIN2 FGF8 FGF8 NFKB2 NFKB2 ESR1 ESR1 TCF7L2 TCF7L2 SOS1 SOS1 EGF EGF FZD3 FZD3 WNT11 WNT11 CDK4 CDK4 SP1 SP1 WNT1 WNT1 CSNK1A1L CSNK1A1L FZD9 FZD9 FZD10 FZD10 FRAT2 FRAT2 AKT3 AKT3 DVL3 DVL3 CDK6 CDK6 RAF1 RAF1 TNFSF11 TNFSF11 FGF20 FGF20 GSK3B GSK3B WNT3A WNT3A MAPK1 MAPK1 AKT1 AKT1 DLL1 DLL1 FGF10 FGF10 FZD7 FZD7 CCND1 CCND1 PIK3R1 PIK3R1 MTOR MTOR LEF1 LEF1 BAK1 BAK1 HEY1 HEY1 FZD4 FZD4 EGFR EGFR SHC3 SHC3 MAP2K1 MAP2K1 WNT8A WNT8A FGF2 FGF2 FGF17 FGF17 NRAS NRAS DLL3 DLL3 GRB2 GRB2 E2F3 E2F3 BRCA1 BRCA1 DVL1 DVL1 POLK POLK FZD2 FZD2 IGF1 IGF1 PIK3R3 PIK3R3 FZD5 FZD5 TCF7 TCF7 FOS FOS NCOA1 NCOA1 ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (513 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TCF7L1Transcription factor 7 like 1. (517 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (764 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RB1RB transcriptional corepressor 1. (919 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BAXUncharacterized protein. (194 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NOTCH2Notch receptor 2. (2444 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3R2Uncharacterized protein. (727 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
NCOA3Nuclear receptor coactivator. (1419 aa)
PGRUncharacterized protein. (339 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
E2F2E2F transcription factor 2. (437 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
E2F1E2F transcription factor 1. (391 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SHC1SHC adaptor protein 1. (542 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (279 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ESR2Estrogen receptor 2. (530 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
AXIN2DIX domain-containing protein. (294 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
NFKB2Nuclear factor kappa B subunit 2. (900 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
TCF7L2HMG box domain-containing protein. (534 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SP1Sp1 transcription factor. (786 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (232 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
DVL3Dishevelled segment polarity protein 3. (673 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (737 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
LEF1Lymphoid enhancer binding factor 1. (386 aa)
BAK1BCL2 antagonist/killer 1. (182 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
SHC3SHC adaptor protein 3. (598 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (287 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DLL3Delta like canonical Notch ligand 3. (619 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
E2F3E2F transcription factor 3. (397 aa)
BRCA1BRCA1 DNA repair associated. (1884 aa)
DVL1Dishevelled segment polarity protein 1. (667 aa)
POLKDNA polymerase kappa. (896 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
IGF1IlGF domain-containing protein. (196 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
TCF7HMG box domain-containing protein. (486 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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