STRINGSTRING
FLT3 FLT3 SCO2 SCO2 HK2 HK2 PFKL PFKL PGAM2 PGAM2 PIK3CB PIK3CB KRAS KRAS SLC2A2 SLC2A2 MYC MYC PDK1 PDK1 PIK3CA PIK3CA PIK3R2 PIK3R2 PDHB PDHB HRAS HRAS KIT KIT PDGFRB PDGFRB PFKP PFKP NTRK3 NTRK3 HKDC1 HKDC1 IDH2 IDH2 PTEN PTEN FGFR1 FGFR1 HK3 HK3 PGAM1 PGAM1 SLC16A3 SLC16A3 SIRT3 SIRT3 RET RET FGFR2 FGFR2 GLS2 GLS2 LDHAL6A LDHAL6A PFKM PFKM PDHA2 PDHA2 LDHAL6B LDHAL6B AKT3 AKT3 RAF1 RAF1 LDHB LDHB MET MET LOC100586354 LOC100586354 MAPK1 MAPK1 AKT1 AKT1 HK1 HK1 LDHC LDHC PIK3R1 PIK3R1 MTOR MTOR EGFR EGFR MAP2K1 MAP2K1 NRAS NRAS TIGAR TIGAR LDHA LDHA PIK3R3 PIK3R3 SLC7A5 SLC7A5 NTRK1 NTRK1 LOC100579290 LOC100579290 HIF1A HIF1A ERBB2 ERBB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
HK2Hexokinase 2. (917 aa)
PFKLPhosphofructokinase, liver type. (726 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PDK1Protein-serine/threonine kinase. (456 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1065 aa)
PIK3R2Uncharacterized protein. (727 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (969 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
PFKP6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (783 aa)
NTRK3Tyrosine-protein kinase receptor. (706 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FGFR1Fibroblast growth factor receptor. (835 aa)
HK3Hexokinase 3. (806 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
SLC16A3Solute carrier family 16 member 3. (465 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (399 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
GLS2Glutaminase 2. (602 aa)
LDHAL6AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (853 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (388 aa)
LDHAL6BL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1413 aa)
LOC100586354L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (354 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (341 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
HK1Hexokinase 1. (881 aa)
LDHCLactate dehydrogenase C. (331 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (716 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2578 aa)
EGFRReceptor protein-tyrosine kinase. (1206 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (478 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
LOC100579290Uncharacterized protein; Belongs to the LDH/MDH superfamily. (370 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ERBB2Receptor protein-tyrosine kinase. (1247 aa)
Your Current Organism:
Nomascus leucogenys
NCBI taxonomy Id: 61853
Other names: Hylobates concolor leucogenys, Hylobates concolor leucogyneus, Hylobates leucogenys, Hylobates leucogenys leucogenys, N. leucogenys, Nomascus leucogenys leucogenys, Nomascus leukogenys, White-cheeked Gibbon, northern white-cheeked gibbon
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